TY - JOUR
T1 - T cells climb on board Blimp-1
AU - Jameson, Stephen C.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/8
Y1 - 2006/8
N2 - B lymphocyte-induced maturation protein (Blimp)-1, a transcriptional repressor, has long been known to drive the terminal maturation of B cells into plasma cells. However, two recent studies reveal an unanticipated role for Blimp-1 in T-cell homeostasis. Blimp-1-deficient T cells exhibit enhanced proliferative and functional responses following activation, and induce spontaneous colitis. Hence, aside from its role in B-cell differentiation, Blimp-1 directs restraint among T cells.
AB - B lymphocyte-induced maturation protein (Blimp)-1, a transcriptional repressor, has long been known to drive the terminal maturation of B cells into plasma cells. However, two recent studies reveal an unanticipated role for Blimp-1 in T-cell homeostasis. Blimp-1-deficient T cells exhibit enhanced proliferative and functional responses following activation, and induce spontaneous colitis. Hence, aside from its role in B-cell differentiation, Blimp-1 directs restraint among T cells.
UR - http://www.scopus.com/inward/record.url?scp=33745828714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745828714&partnerID=8YFLogxK
U2 - 10.1016/j.it.2006.06.002
DO - 10.1016/j.it.2006.06.002
M3 - Short survey
C2 - 16807109
AN - SCOPUS:33745828714
SN - 1471-4906
VL - 27
SP - 349
EP - 351
JO - Trends in Immunology
JF - Trends in Immunology
IS - 8
ER -