T cells climb on board Blimp-1

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations

Abstract

B lymphocyte-induced maturation protein (Blimp)-1, a transcriptional repressor, has long been known to drive the terminal maturation of B cells into plasma cells. However, two recent studies reveal an unanticipated role for Blimp-1 in T-cell homeostasis. Blimp-1-deficient T cells exhibit enhanced proliferative and functional responses following activation, and induce spontaneous colitis. Hence, aside from its role in B-cell differentiation, Blimp-1 directs restraint among T cells.

Original languageEnglish (US)
Pages (from-to)349-351
Number of pages3
JournalTrends in Immunology
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2006

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