T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway

Shengqing Li, Feng Zhu, Tatiana Zykova, Myoung Ok Kim, Yong Yeon Cho, Ann M. Bode, Cong Peng, Wei-Ya Ma, Andria Carper, Alyssa Langfald, Zigang Dong

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Solar UV radiation is a major environmental factor that causes DNA damage, inflammation, and even skin cancer. T-LAK cell-originated protein kinase (TOPK) is expressed widely in both normal and cancer cells and functions to inhibit apoptosis and promote carcinogenesis. However, its function in inflammation is not known. The p38 MAPK signaling pathway plays an important role in solar UV light-induced inflammation. In this study, we found that TOPK negatively regulated the activity of p38α by phosphorylating the p38α-specific phosphatase MKP1 and enhancing the stability of MKP1. Notably, the absence of TOPK in mice resulted in a striking increase in skin inflammation. Therefore, we conclude that TOPK has a protective function in solar UV light-induced inflammation.

Original languageEnglish (US)
Pages (from-to)29601-29609
Number of pages9
JournalJournal of Biological Chemistry
Volume286
Issue number34
DOIs
StatePublished - Aug 26 2011

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