Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders

Allan V. Kalueff; Adam Michael Stewart; Michael Nguyen; Cai Song; Irving I. Gottesman

doi:10.1016/j.pnpbp.2015.05.004

Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders

Allan V. Kalueff, Adam Michael Stewart, Michael Nguyen, Cai Song, Irving I. Gottesman

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.

Original language	English (US)
Pages (from-to)	76-82
Number of pages	7
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	63
DOIs	https://doi.org/10.1016/j.pnpbp.2015.05.004
State	Published - Dec 3 2015

Bibliographical note

Funding Information:
This study is supported by the ZENEREI Institute Intramural Research Program (AVK, AMS) , Guangdong Ocean University RIMND funds (AVK, CS), as well as the Lieber Prize for Schizophrenia Research and the University of Louisville Grawemeyer Award in Psychology (IIG) .

Publisher Copyright:
© 2015 Elsevier Inc.

Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.

Keywords

Drug sensitivity predictor
Drug target
Efficacy
Endophenotype
Psychopharmacotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.",

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AU - Kalueff, Allan V.

AU - Stewart, Adam Michael

AU - Nguyen, Michael

AU - Song, Cai

AU - Gottesman, Irving I.

N1 - Funding Information: This study is supported by the ZENEREI Institute Intramural Research Program (AVK, AMS) , Guangdong Ocean University RIMND funds (AVK, CS), as well as the Lieber Prize for Schizophrenia Research and the University of Louisville Grawemeyer Award in Psychology (IIG) . Publisher Copyright: © 2015 Elsevier Inc. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

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N2 - One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.

AB - One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.

KW - Drug sensitivity predictor

KW - Drug target

KW - Efficacy

KW - Endophenotype

KW - Psychopharmacotherapy

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Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders

Abstract

Bibliographical note

Keywords

UN SDGs

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