Targeting early infection to prevent HIV-1 mucosal transmission

Research output: Contribution to journalReview articlepeer-review

447 Scopus citations

Abstract

Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalNature
Volume464
Issue number7286
DOIs
StatePublished - Mar 11 2010

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