Targeting fibroblast growth factor pathways in endometrial cancer

Boris Winterhoff; Gottfried E. Konecny

doi:10.1016/j.currproblcancer.2016.11.002

Targeting fibroblast growth factor pathways in endometrial cancer

Boris Winterhoff, Gottfried E. Konecny

Obstetrics, Gynecology and Women's Health - Oncology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Novel treatments that improve outcomes for patients with recurrent or metastatic endometrial cancer (EC) remain an unmet need. Aberrant signaling by fibroblast growth factors (FGFs) and FGF receptors (FGFRs) has been implicated in several human cancers. Activating mutations in FGFR2 have been found in up to 16% of ECs, suggesting an opportunity for targeted therapy. This review summarizes the role of the FGF pathway in angiogenesis and EC, and provides an overview of FGFR-targeted therapies under clinical development for the treatment of EC.

Original language	English (US)
Pages (from-to)	37-47
Number of pages	11
Journal	Current Problems in Cancer
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.currproblcancer.2016.11.002
State	Published - Jan 1 2017

Bibliographical note

Publisher Copyright:
© 2017 The Authors

Keywords

Angiogenesis
Endometrial cancer
Fibroblast growth factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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AB - Novel treatments that improve outcomes for patients with recurrent or metastatic endometrial cancer (EC) remain an unmet need. Aberrant signaling by fibroblast growth factors (FGFs) and FGF receptors (FGFRs) has been implicated in several human cancers. Activating mutations in FGFR2 have been found in up to 16% of ECs, suggesting an opportunity for targeted therapy. This review summarizes the role of the FGF pathway in angiogenesis and EC, and provides an overview of FGFR-targeted therapies under clinical development for the treatment of EC.

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Targeting fibroblast growth factor pathways in endometrial cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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