While translational regulation of p53 by the internal ribosome entry site (IRES) at its 50-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.
Bibliographical noteFunding Information:
Funding for this research was provided by an Idea Award (#BC051719) from the Department of Defense, two research grants (1RO3#ES017869, and 1RO3#CA177954) from NIH, an Institutional Research Grant (#118198-IRG-58-001-52-IRG99) from American Cancer Society, and the Hormel Foundation.
© 2017 by the authors; licensee MDPI, Basel, Switzerland.
Copyright 2017 Elsevier B.V., All rights reserved.
- DNA damage
- IRES-trans acting factors (ITAFs)
- Internal ribosome entry site (IRES)