Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate

Naghma Khan, Farrukh Afaq, Mohammad Saleem, Nihal Ahmad, Hasan Mukhtar

Research output: Contribution to journalReview articlepeer-review

597 Scopus citations


Cell signaling pathways, responsible for maintaining a balance between cell proliferation and death, have emerged as rational targets for the management of cancer. Emerging data amassed from various laboratories around the world suggests that green tea, particularly its major polyphenolic constituent (-)-epigallocatechin-3-gallate (EGCG), possesses remarkable cancer chemopreventive and therapeutic potential against various cancer sites in animal tumor bioassay systems and in some human epidemiologic studies. EGCG has been shown to modulate multiple signal transduction pathways in a fashion that controls the unwanted proliferation of cells, thereby imparting strong cancer chemopreventive as well as therapeutic effects. This review discusses the modulations of important signaling events by EGCG and their implications in cancer management.

Original languageEnglish (US)
Pages (from-to)2500-2505
Number of pages6
JournalCancer Research
Issue number5
StatePublished - Mar 1 2006
Externally publishedYes


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