Targeting the Androgen Receptor

Terence W. Friedlander, Charles J. Ryan

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Androgen receptor (AR)-mediated signaling is critical to the growth and survival of prostate cancer. Although medical castration and antiandrogen therapy can decrease AR activity and lower PSA, castration resistance eventually develops. Recent work exploring the molecular structure and evolution of AR in response to hormonal therapies has revealed novel mechanisms of progression of castration-resistant prostate cancer and yielded new targets for drug development. This review focuses on understanding the mechanisms of persistent AR signaling in the castrate environment, and highlights new therapies either currently available or in clinical trials, including androgen synthesis inhibitors and novel direct AR inhibitors.

Original languageEnglish (US)
Pages (from-to)453-464
Number of pages12
JournalUrologic Clinics of North America
Volume39
Issue number4
DOIs
StatePublished - Nov 2012
Externally publishedYes

Bibliographical note

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

  • ARN-509
  • Abiraterone acetate
  • Androgen receptor
  • Castration-resistant prostate cancer
  • EPI-001
  • Galeterone
  • MDV3100
  • Orteronel

Fingerprint Dive into the research topics of 'Targeting the Androgen Receptor'. Together they form a unique fingerprint.

Cite this