Targeting the Gastrointestinal Tract to Develop Novel Therapies for HIV

R. K. Reeves; A. Burgener; N. R. Klatt

doi:10.1002/cpt.186

Targeting the Gastrointestinal Tract to Develop Novel Therapies for HIV

R. K. Reeves, A. Burgener, N. R. Klatt

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Despite the use of antiretroviral therapy (ART), which delays and/or prevents AIDS pathogenesis, human immunodeficiency virus (HIV)- infected individuals continue to face increased morbidities and mortality rates compared with uninfected individuals. Gastrointestinal (GI) mucosal dysfunction is a key feature of HIV infection, and is associated with mortality. In this study, we review current knowledge about mucosal dysfunction in HIV infection, and describe potential avenues for therapeutic targets to enhance mucosal function and decrease morbidities and mortalities in HIV-infected individuals.

Original language	English (US)
Pages (from-to)	381-386
Number of pages	6
Journal	Clinical pharmacology and therapeutics
Volume	98
Issue number	4
DOIs	https://doi.org/10.1002/cpt.186
State	Published - Oct 1 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015, The American Society for Clinical Pharmacology and Therapeutics.

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AB - Despite the use of antiretroviral therapy (ART), which delays and/or prevents AIDS pathogenesis, human immunodeficiency virus (HIV)- infected individuals continue to face increased morbidities and mortality rates compared with uninfected individuals. Gastrointestinal (GI) mucosal dysfunction is a key feature of HIV infection, and is associated with mortality. In this study, we review current knowledge about mucosal dysfunction in HIV infection, and describe potential avenues for therapeutic targets to enhance mucosal function and decrease morbidities and mortalities in HIV-infected individuals.

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Targeting the Gastrointestinal Tract to Develop Novel Therapies for HIV

Abstract

Bibliographical note

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