Taxol Photoaffinity Label: 7-(p-Azidobenzoyl)taxol Synthesis and Biological Evaluation

Gunda I. George, Geraldine C.B. Harriman, Richard H. Himes, Magdalena R. Mejillano

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (4) and 7-(p-azidobenzoyl)baccatin III (3) is described which leads to the targeted biologically active taxol photoaffinity label 6.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number7
DOIs
StatePublished - Jul 1992

Keywords

  • Taxol
  • microtubule assembly
  • photoaffinity label.
  • synthesis
  • β-lactams

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