Telomerase activity, Myc and Bcl-2: Possible indicators of effective therapy of prostate cancer with 9-nitrocamptothecin

D. Chatterjee; J. H. Wyche; D. P. Romero; P. Pantazis

Telomerase activity, Myc and Bcl-2: Possible indicators of effective therapy of prostate cancer with 9-nitrocamptothecin

D. Chatterjee, J. H. Wyche, D. P. Romero, P. Pantazis

Pharmacology

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6 Scopus citations

Abstract

In this report, we demonstrate the down-regulation of telomerase activity and c-Myc and Bcl-2 expression during 9-nitrocamptothecin (9NC)-induced regression of human DU145 prostate tumors grown as xenografts in immunodeficient mice. These changes were not observed in tumors generated by DU145-derived cells resistant to 9NC. We suggest that telomerase activity, c-Myc and Bcl-2 can collectively serve as molecular diagnostic indicators of the effectiveness of 9NC during treatment of human prostate tumors.

Original language	English (US)
Pages (from-to)	2885-2889
Number of pages	5
Journal	Anticancer Research
Volume	20
Issue number	5
State	Published - 2000

Keywords

9-Nitrocamptothecin
Myc
Prostate cancer
Telomerase

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abstract = "In this report, we demonstrate the down-regulation of telomerase activity and c-Myc and Bcl-2 expression during 9-nitrocamptothecin (9NC)-induced regression of human DU145 prostate tumors grown as xenografts in immunodeficient mice. These changes were not observed in tumors generated by DU145-derived cells resistant to 9NC. We suggest that telomerase activity, c-Myc and Bcl-2 can collectively serve as molecular diagnostic indicators of the effectiveness of 9NC during treatment of human prostate tumors.",

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T2 - Possible indicators of effective therapy of prostate cancer with 9-nitrocamptothecin

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AU - Wyche, J. H.

AU - Romero, D. P.

AU - Pantazis, P.

PY - 2000

Y1 - 2000

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AB - In this report, we demonstrate the down-regulation of telomerase activity and c-Myc and Bcl-2 expression during 9-nitrocamptothecin (9NC)-induced regression of human DU145 prostate tumors grown as xenografts in immunodeficient mice. These changes were not observed in tumors generated by DU145-derived cells resistant to 9NC. We suggest that telomerase activity, c-Myc and Bcl-2 can collectively serve as molecular diagnostic indicators of the effectiveness of 9NC during treatment of human prostate tumors.

KW - 9-Nitrocamptothecin

KW - Myc

KW - Prostate cancer

KW - Telomerase

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Telomerase activity, Myc and Bcl-2: Possible indicators of effective therapy of prostate cancer with 9-nitrocamptothecin

Abstract

Keywords

UN SDGs

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