Telomerase activity, Myc and Bcl-2: Possible indicators of effective therapy of prostate cancer with 9-nitrocamptothecin

D. Chatterjee, J. H. Wyche, D. P. Romero, P. Pantazis

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In this report, we demonstrate the down-regulation of telomerase activity and c-Myc and Bcl-2 expression during 9-nitrocamptothecin (9NC)-induced regression of human DU145 prostate tumors grown as xenografts in immunodeficient mice. These changes were not observed in tumors generated by DU145-derived cells resistant to 9NC. We suggest that telomerase activity, c-Myc and Bcl-2 can collectively serve as molecular diagnostic indicators of the effectiveness of 9NC during treatment of human prostate tumors.

Original languageEnglish (US)
Pages (from-to)2885-2889
Number of pages5
JournalAnticancer Research
Volume20
Issue number5
StatePublished - Nov 9 2000

Keywords

  • 9-Nitrocamptothecin
  • Myc
  • Prostate cancer
  • Telomerase

Fingerprint

Dive into the research topics of 'Telomerase activity, Myc and Bcl-2: Possible indicators of effective therapy of prostate cancer with 9-nitrocamptothecin'. Together they form a unique fingerprint.

Cite this