Telomere correlations during early life in a long-lived seabird

Jacob E. Schmidt; Aubrey E. Sirman; Jeffrey D. Kittilson; Mark E. Clark; Wendy L. Reed; Britt J. Heidinger

doi:10.1016/j.exger.2016.09.011

Telomere correlations during early life in a long-lived seabird

Jacob E. Schmidt, Aubrey E. Sirman, Jeffrey D. Kittilson, Mark E. Clark, Wendy L. Reed, Britt J. Heidinger

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Telomere dynamics in blood cells have been linked to aging in a variety of organisms. However, whether blood telomeres are correlated with telomeres in other parts of the body is not well known, especially during early life when telomere loss is expected to be most rapid. We investigated this question in Franklin's gulls (Leucophaeus pipixcan) by measuring telomere lengths in blood and several other tissues including: heart, liver, and skeletal muscle at the end of embryonic (n = 31) and post-natal development (n = 20). In late-stage embryos, blood telomeres were significantly positively correlated with heart and skeletal muscle, but not liver telomeres. However, at the end of post-natal development, there were no significant correlations among blood telomeres and telomeres in any other tissues. In late-stage embryos, heart telomeres were significantly longer than blood, liver, and skeletal muscle telomeres, but at the end of post-natal development telomere lengths did not significantly differ among tissues. These results suggest that blood telomere length is not necessarily indicative of other tissues at all stages of development and highlights the importance of understanding any functional consequences of tissue specific telomere dynamics in early life.

Original language	English (US)
Pages (from-to)	28-32
Number of pages	5
Journal	Experimental Gerontology
Volume	85
DOIs	https://doi.org/10.1016/j.exger.2016.09.011
State	Published - Dec 1 2016
Externally published	Yes

Bibliographical note

Funding Information:
We are grateful to Alexandra Hett, Grant Edland, Soren Hjort, David Breitbach, and Aaron Kaip for assistance with animal husbandry, to Aurelia Kucera for help with sample collection, and to the rest of our lab group for support and feedback throughout the experiment. All of the experimental procedures were approved by the North Dakota State University IACUC (A13056 and A15066). This work was funded by a ND EPSCoR award ( FAR0022429 ) to BJH. The authors do not have any competing interests.

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Aging
Early-life
Franklin's gull (Leucophaeus pipixcan)
Longevity
Senescence
Telomere

Access

10.1016/j.exger.2016.09.011

OpenUrl availability

Full text

Cite this

@article{8f3364d009d14aa095fa4051573ab4bb,

title = "Telomere correlations during early life in a long-lived seabird",

abstract = "Telomere dynamics in blood cells have been linked to aging in a variety of organisms. However, whether blood telomeres are correlated with telomeres in other parts of the body is not well known, especially during early life when telomere loss is expected to be most rapid. We investigated this question in Franklin's gulls (Leucophaeus pipixcan) by measuring telomere lengths in blood and several other tissues including: heart, liver, and skeletal muscle at the end of embryonic (n = 31) and post-natal development (n = 20). In late-stage embryos, blood telomeres were significantly positively correlated with heart and skeletal muscle, but not liver telomeres. However, at the end of post-natal development, there were no significant correlations among blood telomeres and telomeres in any other tissues. In late-stage embryos, heart telomeres were significantly longer than blood, liver, and skeletal muscle telomeres, but at the end of post-natal development telomere lengths did not significantly differ among tissues. These results suggest that blood telomere length is not necessarily indicative of other tissues at all stages of development and highlights the importance of understanding any functional consequences of tissue specific telomere dynamics in early life.",

keywords = "Aging, Early-life, Franklin's gull (Leucophaeus pipixcan), Longevity, Senescence, Telomere",

author = "Schmidt, {Jacob E.} and Sirman, {Aubrey E.} and Kittilson, {Jeffrey D.} and Clark, {Mark E.} and Reed, {Wendy L.} and Heidinger, {Britt J.}",

note = "Funding Information: We are grateful to Alexandra Hett, Grant Edland, Soren Hjort, David Breitbach, and Aaron Kaip for assistance with animal husbandry, to Aurelia Kucera for help with sample collection, and to the rest of our lab group for support and feedback throughout the experiment. All of the experimental procedures were approved by the North Dakota State University IACUC (A13056 and A15066). This work was funded by a ND EPSCoR award ( FAR0022429 ) to BJH. The authors do not have any competing interests. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = dec,

day = "1",

doi = "10.1016/j.exger.2016.09.011",

language = "English (US)",

volume = "85",

pages = "28--32",

journal = "Experimental Gerontology",

issn = "0531-5565",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Telomere correlations during early life in a long-lived seabird

AU - Schmidt, Jacob E.

AU - Sirman, Aubrey E.

AU - Kittilson, Jeffrey D.

AU - Clark, Mark E.

AU - Reed, Wendy L.

AU - Heidinger, Britt J.

N1 - Funding Information: We are grateful to Alexandra Hett, Grant Edland, Soren Hjort, David Breitbach, and Aaron Kaip for assistance with animal husbandry, to Aurelia Kucera for help with sample collection, and to the rest of our lab group for support and feedback throughout the experiment. All of the experimental procedures were approved by the North Dakota State University IACUC (A13056 and A15066). This work was funded by a ND EPSCoR award ( FAR0022429 ) to BJH. The authors do not have any competing interests. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Telomere dynamics in blood cells have been linked to aging in a variety of organisms. However, whether blood telomeres are correlated with telomeres in other parts of the body is not well known, especially during early life when telomere loss is expected to be most rapid. We investigated this question in Franklin's gulls (Leucophaeus pipixcan) by measuring telomere lengths in blood and several other tissues including: heart, liver, and skeletal muscle at the end of embryonic (n = 31) and post-natal development (n = 20). In late-stage embryos, blood telomeres were significantly positively correlated with heart and skeletal muscle, but not liver telomeres. However, at the end of post-natal development, there were no significant correlations among blood telomeres and telomeres in any other tissues. In late-stage embryos, heart telomeres were significantly longer than blood, liver, and skeletal muscle telomeres, but at the end of post-natal development telomere lengths did not significantly differ among tissues. These results suggest that blood telomere length is not necessarily indicative of other tissues at all stages of development and highlights the importance of understanding any functional consequences of tissue specific telomere dynamics in early life.

AB - Telomere dynamics in blood cells have been linked to aging in a variety of organisms. However, whether blood telomeres are correlated with telomeres in other parts of the body is not well known, especially during early life when telomere loss is expected to be most rapid. We investigated this question in Franklin's gulls (Leucophaeus pipixcan) by measuring telomere lengths in blood and several other tissues including: heart, liver, and skeletal muscle at the end of embryonic (n = 31) and post-natal development (n = 20). In late-stage embryos, blood telomeres were significantly positively correlated with heart and skeletal muscle, but not liver telomeres. However, at the end of post-natal development, there were no significant correlations among blood telomeres and telomeres in any other tissues. In late-stage embryos, heart telomeres were significantly longer than blood, liver, and skeletal muscle telomeres, but at the end of post-natal development telomere lengths did not significantly differ among tissues. These results suggest that blood telomere length is not necessarily indicative of other tissues at all stages of development and highlights the importance of understanding any functional consequences of tissue specific telomere dynamics in early life.

KW - Aging

KW - Early-life

KW - Franklin's gull (Leucophaeus pipixcan)

KW - Longevity

KW - Senescence

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=84988643573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988643573&partnerID=8YFLogxK

U2 - 10.1016/j.exger.2016.09.011

DO - 10.1016/j.exger.2016.09.011

M3 - Article

C2 - 27633529

AN - SCOPUS:84988643573

SN - 0531-5565

VL - 85

SP - 28

EP - 32

JO - Experimental Gerontology

JF - Experimental Gerontology

ER -

Telomere correlations during early life in a long-lived seabird

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this