Ten years of donor-derived disease: A report of the disease transmission advisory committee

Daniel R. Kaul, Gabe Vece, Emily Blumberg, Ricardo M. La Hoz, Michael G. Ison, Michael Green, Timothy Pruett, Michael A. Nalesnik, Susan M. Tlusty, Amber R. Wilk, Cameron R. Wolfe, Marian G. Michaels

Research output: Contribution to journalArticlepeer-review

Abstract

Despite clinical and laboratory screening of potential donors for transmissible disease, unexpected transmission of disease from donor to recipient remains an inherent risk of organ transplantation. The Disease Transmission Advisory Committee (DTAC) was created to review and classify reports of potential disease transmission and use this information to inform national policy and improve patient safety. From January 1, 2008 to December 31, 2017, the DTAC received 2185 reports; 335 (15%) were classified as a proven/probable donor transmission event. Infections were transmitted most commonly (67%), followed by malignancies (29%), and other disease processes (6%). Forty-six percent of recipients receiving organs from a donor that transmitted disease to at least 1 recipient developed a donor-derived disease (DDD). Sixty-seven percent of recipients developed symptoms of DDD within 30 days of transplantation, and all bacterial infections were recognized within 45 days. Graft loss or death occurred in about one third of recipients with DDD, with higher rates associated with malignancy transmission and parasitic and fungal diseases. Unexpected DDD was rare, occurring in 0.18% of all transplant recipients. These findings will help focus future efforts to recognize and prevent DDD.

Original languageEnglish (US)
Pages (from-to)689-702
Number of pages14
JournalAmerican Journal of Transplantation
Volume21
Issue number2
DOIs
StatePublished - Feb 2021

Bibliographical note

Funding Information:
This work was conducted under the auspices of the United Network for Organ Sharing (UNOS), contractor for OPTN, under Contract 250-2019-00001C (US Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation). The data reported here have been supplied by UNOS as the contractor for the OPTN. The interpretation and reporting of these data are the responsibility of the author(s) and should not be seen as an official policy of or interpretation by the OPTN or the US Government.

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