TY - JOUR
T1 - Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw
T2 - a case report and narrative review.
AU - Thumbigere-Math, Vivek
AU - Gopalakrishnan, Rajaram
AU - Michalowicz, Bryan S
PY - 2013
Y1 - 2013
N2 - Bisphosphonates (BP), potent antresorptive agents, play a key role in managing osteolytic bone disorders including osteoporosis, Paget's disease, bone metastasis, and multiple myeloma. However, their long-term administration is associated with increased risk for bisphosphonate-related osteonecrosis of the jaw (BRONJ) development. At present, there is no curative therapy for BRONJ, and patients are often treated palliatively with antibiotics, antimicrobial mouth rinses, and debridement of necrotic bone. This article highlights a new treatment modality that may be beneficial to a subset of osteoporosis patients suffering from BRONJ. Here we report a BRONJ case that was initially unresponsive to conservative treatment, but subsequently responded to teriparatide (recombinant human PTH1-34) therapy.
AB - Bisphosphonates (BP), potent antresorptive agents, play a key role in managing osteolytic bone disorders including osteoporosis, Paget's disease, bone metastasis, and multiple myeloma. However, their long-term administration is associated with increased risk for bisphosphonate-related osteonecrosis of the jaw (BRONJ) development. At present, there is no curative therapy for BRONJ, and patients are often treated palliatively with antibiotics, antimicrobial mouth rinses, and debridement of necrotic bone. This article highlights a new treatment modality that may be beneficial to a subset of osteoporosis patients suffering from BRONJ. Here we report a BRONJ case that was initially unresponsive to conservative treatment, but subsequently responded to teriparatide (recombinant human PTH1-34) therapy.
UR - http://www.scopus.com/inward/record.url?scp=84879160589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879160589&partnerID=8YFLogxK
M3 - Review article
C2 - 23516715
AN - SCOPUS:84879160589
SN - 0022-1120
VL - 92
SP - 12
EP - 18
JO - Unknown Journal
JF - Unknown Journal
IS - 1
ER -