Terminal transferase levels in chronic myelogenous leukemia in blast crisis and in remission

M. M. Oken, P. S. Sarin, R. C. Gallo, Gerhard J Johnson, B. J. Gormus, R. E. Rydell, M. E. Kaplan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Terminal deoxynucleotidyl transferase (TdT) has been cited as a possible biological marker for acute lymphoblastic leukemia (ALL) and the blast phase of chronic myeloid leukemia (CML). In the present study high levels of TdT, comparable to levels present in normal thymus, were observed in circulating leukocytes of a CML patient in blast crisis. Sequential studies revealed disappearance of TdT from circulating leukocytes after remission was induced with vincristine and prednisone therapy. Blood TdT returned to moderately elevated levels in the absence of detectable circulating blasts, 5 months before the reappearance of blast crisis. During blast crisis the malignant cells were devoid of myeloid features on light and electron microscopy and were peroxidase negative and periodic acid-Schiff (PAS) positive. These studies demonstrate that elevated TdT levels may occur with or without detectable morphologic evidence of circulating blast cells. The presence of complement receptors on agranular blasts during the blast phase of chronic myeloid leukemia is a new finding.

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalLeukemia research
Issue number2
StatePublished - 1978

Bibliographical note

Funding Information:
M. M. OKEN, P. S. SARIN,* R. C. GALLO,* G. J. JOHNSON, B. J. GORMUS, R. E. RYDELL and M. E. KAPLAN Department of Medicine and Pathology, Minneapolis Veterans Administration Hospital and the University of Minnesota, Minneapolis, MN 55417 and the Laboratory of Tumor Cell Biology,* National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A.


Dive into the research topics of 'Terminal transferase levels in chronic myelogenous leukemia in blast crisis and in remission'. Together they form a unique fingerprint.

Cite this