Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration

William S. Boyle, Weili Chen, Astrid Rodriguez, Samantha Linn, Jakub Tolar, Karen Lozano, Theresa M. Reineke

Research output: Contribution to journalArticlepeer-review

Abstract

Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.

Original languageEnglish (US)
Pages (from-to)619-624
Number of pages6
JournalACS Applied Bio Materials
Volume2
Issue number2
DOIs
StatePublished - Feb 18 2019

Keywords

  • carbohydrates
  • epidermolysis bullosa
  • Forcespinning
  • nanofibers
  • wound healing

How much support was provided by MRSEC?

  • Shared

Reporting period for MRSEC

  • Period 5

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