Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration

William S. Boyle; Weili Chen; Astrid Rodriguez; Samantha Linn; Jakub Tolar; Karen Lozano; Theresa M. Reineke

doi:10.1021/acsabm.8b00690

Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration

William S. Boyle, Weili Chen, Astrid Rodriguez, Samantha Linn, Jakub Tolar, Karen Lozano, Theresa M. Reineke

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.

Original language	English (US)
Pages (from-to)	619-624
Number of pages	6
Journal	ACS Applied Bio Materials
Volume	2
Issue number	2
DOIs	https://doi.org/10.1021/acsabm.8b00690
State	Published - Feb 18 2019

Keywords

carbohydrates
epidermolysis bullosa
Forcespinning
nanofibers
wound healing

How much support was provided by MRSEC?

Shared

Reporting period for MRSEC

Period 5

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1021/acsabm.8b00690

http://pubs.acs.org/doi/10.1021/acsabm.8b00690

OpenUrl availability

Full text

Cite this

@article{66dda4a70a7143969c1c98275211a895,

title = "Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration",

abstract = "Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.",

keywords = "carbohydrates, epidermolysis bullosa, Forcespinning, nanofibers, wound healing",

author = "Boyle, {William S.} and Weili Chen and Astrid Rodriguez and Samantha Linn and Jakub Tolar and Karen Lozano and Reineke, {Theresa M.}",

year = "2019",

month = feb,

day = "18",

doi = "10.1021/acsabm.8b00690",

language = "English (US)",

volume = "2",

pages = "619--624",

journal = "ACS Applied Bio Materials",

issn = "2576-6422",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration

AU - Boyle, William S.

AU - Chen, Weili

AU - Rodriguez, Astrid

AU - Linn, Samantha

AU - Tolar, Jakub

AU - Lozano, Karen

AU - Reineke, Theresa M.

PY - 2019/2/18

Y1 - 2019/2/18

N2 - Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.

AB - Recessive dystrophic epidermolysis bullosa (RDEB), an inherited disease featuring blistering wounds, causes constant inflammation that leads to the eventual development of an aggressive form of squamous cell carcinoma (RDEB SCC). The persistence of inflammatory chemokines such as MCP-1 and Il-8 in RDEB wounds may foster RDEB SCC carcinogenesis. We report the production of ternary composite nanofibers containing pullulan, chondroitin sulfate, and tannic acid as RDEB wound dressings. The swellable fibers are stable to hydration and absorb ∼500% their weight in water. The fibers remove ∼99% of MCP-1 from solution in <2 h. Scavenged media did not promote RDEB SCC migration.

KW - carbohydrates

KW - epidermolysis bullosa

KW - Forcespinning

KW - nanofibers

KW - wound healing

UR - http://www.scopus.com/inward/record.url?scp=85072768449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072768449&partnerID=8YFLogxK

U2 - 10.1021/acsabm.8b00690

DO - 10.1021/acsabm.8b00690

M3 - Article

C2 - 35016300

SN - 2576-6422

VL - 2

SP - 619

EP - 624

JO - ACS Applied Bio Materials

JF - ACS Applied Bio Materials

IS - 2

ER -

Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration

Abstract

Keywords

How much support was provided by MRSEC?

Reporting period for MRSEC

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

MRSEC IRG-3: Hierarchical Multifunctional Macromolecular Materials

Partnership for Research and Education in Materials

University of Minnesota MRSEC (DMR-1420013)

Cite this

Ternary Composite Nanofibers Containing Chondroitin Sulfate Scavenge Inflammatory Chemokines from Solution and Prohibit Squamous Cell Carcinoma Migration

Abstract

Keywords

How much support was provided by MRSEC?

Reporting period for MRSEC

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Projects

MRSEC IRG-3: Hierarchical Multifunctional Macromolecular Materials

Partnership for Research and Education in Materials

University of Minnesota MRSEC (DMR-1420013)

Cite this