TY - JOUR
T1 - Tetanus vaccination and risk of multiple sclerosis
T2 - A systematic review
AU - Hernán, Miguel A.
AU - Alonso, Alvaro
AU - Hernández-Díaz, Sonia
PY - 2006/7
Y1 - 2006/7
N2 - OBJECTIVE: To conduct a systematic review on the association between tetanus vaccination and the risk of multiple sclerosis (MS). METHODS: The authors searched the databases Medline, LILACS, EMBASE, and Science Citation Index including the period 1966 to September 1, 2005. Eligible studies had to meet the following inclusion criteria: presentation of original data, case-control or cohort design, physician-confirmed diagnosis of MS as the outcome of interest, attempt to ascertain vaccinations in a period before the diagnosis, and report of an association measure between tetanus vaccination and incidence of MS, and its 95% CI or enough information to compute it. Study specific log ORs were weighted by the inverse of their variances to obtain a pooled estimate and its 95% CI. RESULTS: The OR of MS associated with history of tetanus vaccination was 0.67 (95% CI: 0.55 to 0.81). There was little indication of heterogeneity of results across studies. CONCLUSION: Tetanus vaccination is associated with a lower risk of multiple sclerosis.
AB - OBJECTIVE: To conduct a systematic review on the association between tetanus vaccination and the risk of multiple sclerosis (MS). METHODS: The authors searched the databases Medline, LILACS, EMBASE, and Science Citation Index including the period 1966 to September 1, 2005. Eligible studies had to meet the following inclusion criteria: presentation of original data, case-control or cohort design, physician-confirmed diagnosis of MS as the outcome of interest, attempt to ascertain vaccinations in a period before the diagnosis, and report of an association measure between tetanus vaccination and incidence of MS, and its 95% CI or enough information to compute it. Study specific log ORs were weighted by the inverse of their variances to obtain a pooled estimate and its 95% CI. RESULTS: The OR of MS associated with history of tetanus vaccination was 0.67 (95% CI: 0.55 to 0.81). There was little indication of heterogeneity of results across studies. CONCLUSION: Tetanus vaccination is associated with a lower risk of multiple sclerosis.
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U2 - 10.1212/01.wnl.0000225079.51201.f9
DO - 10.1212/01.wnl.0000225079.51201.f9
M3 - Review article
C2 - 16864810
AN - SCOPUS:33747073189
SN - 0028-3878
VL - 67
SP - 212
EP - 215
JO - Neurology
JF - Neurology
IS - 2
ER -
