The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Kristin M. Linner; Barbara J. Stickney; Heidi E. Quist; Burt M. Sharp; Philip S. Portoghese

doi:10.1016/S0014-2999(98)00477-4

The δ₁-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Kristin M. Linner, Barbara J. Stickney, Heidi E. Quist, Burt M. Sharp, Philip S. Portoghese

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ₁-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ₁-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	R3-R5
Journal	European Journal of Pharmacology
Volume	354
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(98)00477-4
State	Published - Jul 31 1998

Bibliographical note

Funding Information:
This work was supported by a grant from Hennepin Faculty Associates and by the Department of Medicine at Hennepin County Medical Center, Minneapolis, MN, as well as by PHS grants 2S07RR06019-04, DA01533, DA04196 and T32-DA07239.

Keywords

7-Benzylspiroindanylnaltrexone
Transplantation
δ-Opioid receptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/S0014-2999(98)00477-4

OpenUrl availability

Full text

Cite this

@article{796a619ca29a423ba2b2cf96bee4417b,

title = "The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model",

abstract = "In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.",

keywords = "7-Benzylspiroindanylnaltrexone, Transplantation, δ-Opioid receptor",

author = "Linner, {Kristin M.} and Stickney, {Barbara J.} and Quist, {Heidi E.} and Sharp, {Burt M.} and Portoghese, {Philip S.}",

note = "Funding Information: This work was supported by a grant from Hennepin Faculty Associates and by the Department of Medicine at Hennepin County Medical Center, Minneapolis, MN, as well as by PHS grants 2S07RR06019-04, DA01533, DA04196 and T32-DA07239.",

year = "1998",

month = jul,

day = "31",

doi = "10.1016/S0014-2999(98)00477-4",

language = "English (US)",

volume = "354",

pages = "R3--R5",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

AU - Linner, Kristin M.

AU - Stickney, Barbara J.

AU - Quist, Heidi E.

AU - Sharp, Burt M.

AU - Portoghese, Philip S.

N1 - Funding Information: This work was supported by a grant from Hennepin Faculty Associates and by the Department of Medicine at Hennepin County Medical Center, Minneapolis, MN, as well as by PHS grants 2S07RR06019-04, DA01533, DA04196 and T32-DA07239.

PY - 1998/7/31

Y1 - 1998/7/31

N2 - In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.

AB - In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.

KW - 7-Benzylspiroindanylnaltrexone

KW - Transplantation

KW - δ-Opioid receptor

UR - http://www.scopus.com/inward/record.url?scp=0031658880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031658880&partnerID=8YFLogxK

U2 - 10.1016/S0014-2999(98)00477-4

DO - 10.1016/S0014-2999(98)00477-4

M3 - Article

C2 - 9726640

AN - SCOPUS:0031658880

SN - 0014-2999

VL - 354

SP - R3-R5

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -