The δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone, prolongs renal allograft survival in a rat model

Kristin M. Linner, Barbara J. Stickney, Heidi E. Quist, Burt M. Sharp, Philip S. Portoghese

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Abstract

In this study we demonstrate allograft survival in a rat model of renal transplantation using the δ1-opioid receptor antagonist, 7-benzylspiroindanylnaltrexone. Treatment with 7-benzylspiroindanylnaltrexone caused 50% of the rats to survive longer than 100 days (untreated, 11±3 days). Naltrindole, a δ-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at δ1-opioid receptors is involved in allograft survival. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)R3-R5
JournalEuropean Journal of Pharmacology
Volume354
Issue number1
DOIs
StatePublished - Jul 31 1998

Bibliographical note

Funding Information:
This work was supported by a grant from Hennepin Faculty Associates and by the Department of Medicine at Hennepin County Medical Center, Minneapolis, MN, as well as by PHS grants 2S07RR06019-04, DA01533, DA04196 and T32-DA07239.

Keywords

  • 7-Benzylspiroindanylnaltrexone
  • Transplantation
  • δ-Opioid receptor

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