The 2-His-1-carboxylate facial triad - An emerging structural motif in mononuclear non-heme iron(II) enzymes

Eric L. Hegg, Lawrence Que

Research output: Contribution to journalReview articlepeer-review

435 Scopus citations

Abstract

A 2-His-1-carboxylate facial triad is a common feature of the active sites in a number of mononuclear nen-heme iron(II) enzymes. This structural motif was established crystallographically for five different classes of enzymes and inferred from sequence similarity for two other classes. The 2-His-1-carboxylate facial triad anchors the iron in the active site and at the same time maintains three additional cis-oriented sites. These sites can be used to bind other endogenous ligands or exogenous ligands such as substrate and/or O2, giving the metal center great flexibility to use different mechanistic strategies to perform a variety of chemical transformations.

Original languageEnglish (US)
Pages (from-to)625-629
Number of pages5
JournalEuropean Journal of Biochemistry
Volume250
Issue number3
DOIs
StatePublished - Dec 15 1997

Keywords

  • 2-His-1-carboxylate facial triad
  • Non-heme
  • Oxygenase

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