The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study

Vijay Nambi, Eric Boerwinkle, Kim Lawson, Ariel Brautbar, Lloyd Chambless, Nora Franeschini, Kari E. North, Salim S. Virani, Aaron R. Folsom, Christie M. Ballantyne

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objective: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. Methods: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n= 9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated. Results: The AUC of the ACRS, ACRS. +. 9p21, ACRS. +. CIMT-P and ACRS. +. CIMT-P. +. 9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript). Conclusion: Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study.

Original languageEnglish (US)
Pages (from-to)135-137
Number of pages3
JournalAtherosclerosis
Volume222
Issue number1
DOIs
StatePublished - May 2012

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ), R01HL087641 , R01HL59367 and R01HL086694 ; National Human Genome Research Institute contract U01HG004402 ; and National Institutes of Health contract HHSN268200625226C . The authors thank the staff and participants of the ARIC study for their important contributions. Infrastructure was partly supported by Grant Number UL1RR025005 , a component of the National Institutes of Health and NIH Roadmap for Medical Research. DR Nambi is supported by grant K23 HL096893 from the National Institutes of Health/National Heart, Lung, and Blood Institute . He has research collaboration with GE

Keywords

  • 9p21
  • Carotid intima media thickness
  • Coronary heart disease
  • Plaque
  • Risk prediction

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