The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study

Vijay Nambi; Eric Boerwinkle; Kim Lawson; Ariel Brautbar; Lloyd Chambless; Nora Franeschini; Kari E. North; Salim S. Virani; Aaron R. Folsom; Christie M. Ballantyne

doi:10.1016/j.atherosclerosis.2012.01.028

The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study

Vijay Nambi, Eric Boerwinkle, Kim Lawson, Ariel Brautbar, Lloyd Chambless, Nora Franeschini, Kari E. North, Salim S. Virani, Aaron R. Folsom, Christie M. Ballantyne

Epidemiology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. Methods: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n= 9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated. Results: The AUC of the ACRS, ACRS. +. 9p21, ACRS. +. CIMT-P and ACRS. +. CIMT-P. +. 9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript). Conclusion: Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study.

Original language	English (US)
Pages (from-to)	135-137
Number of pages	3
Journal	Atherosclerosis
Volume	222
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.01.028
State	Published - May 2012

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ), R01HL087641 , R01HL59367 and R01HL086694 ; National Human Genome Research Institute contract U01HG004402 ; and National Institutes of Health contract HHSN268200625226C . The authors thank the staff and participants of the ARIC study for their important contributions. Infrastructure was partly supported by Grant Number UL1RR025005 , a component of the National Institutes of Health and NIH Roadmap for Medical Research. DR Nambi is supported by grant K23 HL096893 from the National Institutes of Health/National Heart, Lung, and Blood Institute . He has research collaboration with GE

Keywords

9p21
Carotid intima media thickness
Coronary heart disease
Plaque
Risk prediction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Nambi, V., Boerwinkle, E., Lawson, K., Brautbar, A., Chambless, L., Franeschini, N., North, K. E., Virani, S. S., Folsom, A. R., & Ballantyne, C. M. (2012). The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis, 222(1), 135-137. https://doi.org/10.1016/j.atherosclerosis.2012.01.028

The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study. / Nambi, Vijay; Boerwinkle, Eric; Lawson, Kim et al.
In: Atherosclerosis, Vol. 222, No. 1, 05.2012, p. 135-137.

Research output: Contribution to journal › Article › peer-review

Nambi, V, Boerwinkle, E, Lawson, K, Brautbar, A, Chambless, L, Franeschini, N, North, KE, Virani, SS, Folsom, AR & Ballantyne, CM 2012, 'The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study', Atherosclerosis, vol. 222, no. 1, pp. 135-137. https://doi.org/10.1016/j.atherosclerosis.2012.01.028

Nambi V, Boerwinkle E, Lawson K, Brautbar A, Chambless L, Franeschini N et al. The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis. 2012 May;222(1):135-137. doi: 10.1016/j.atherosclerosis.2012.01.028

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title = "The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study",

abstract = "Objective: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. Methods: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n= 9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated. Results: The AUC of the ACRS, ACRS. +. 9p21, ACRS. +. CIMT-P and ACRS. +. CIMT-P. +. 9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript). Conclusion: Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study.",

keywords = "9p21, Carotid intima media thickness, Coronary heart disease, Plaque, Risk prediction",

author = "Vijay Nambi and Eric Boerwinkle and Kim Lawson and Ariel Brautbar and Lloyd Chambless and Nora Franeschini and North, {Kari E.} and Virani, {Salim S.} and Folsom, {Aaron R.} and Ballantyne, {Christie M.}",

note = "Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ), R01HL087641 , R01HL59367 and R01HL086694 ; National Human Genome Research Institute contract U01HG004402 ; and National Institutes of Health contract HHSN268200625226C . The authors thank the staff and participants of the ARIC study for their important contributions. Infrastructure was partly supported by Grant Number UL1RR025005 , a component of the National Institutes of Health and NIH Roadmap for Medical Research. DR Nambi is supported by grant K23 HL096893 from the National Institutes of Health/National Heart, Lung, and Blood Institute . He has research collaboration with GE ",

year = "2012",

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doi = "10.1016/j.atherosclerosis.2012.01.028",

language = "English (US)",

volume = "222",

pages = "135--137",

journal = "Atherosclerosis",

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number = "1",

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TY - JOUR

T1 - The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study

AU - Nambi, Vijay

AU - Boerwinkle, Eric

AU - Lawson, Kim

AU - Brautbar, Ariel

AU - Chambless, Lloyd

AU - Franeschini, Nora

AU - North, Kari E.

AU - Virani, Salim S.

AU - Folsom, Aaron R.

AU - Ballantyne, Christie M.

N1 - Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts ( HHSN268201100005C , HHSN268201100006C , HHSN268201100007C , HHSN268201100008C , HHSN268201100009C , HHSN268201100010C , HHSN268201100011C , and HHSN268201100012C ), R01HL087641 , R01HL59367 and R01HL086694 ; National Human Genome Research Institute contract U01HG004402 ; and National Institutes of Health contract HHSN268200625226C . The authors thank the staff and participants of the ARIC study for their important contributions. Infrastructure was partly supported by Grant Number UL1RR025005 , a component of the National Institutes of Health and NIH Roadmap for Medical Research. DR Nambi is supported by grant K23 HL096893 from the National Institutes of Health/National Heart, Lung, and Blood Institute . He has research collaboration with GE

PY - 2012/5

Y1 - 2012/5

N2 - Objective: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. Methods: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n= 9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated. Results: The AUC of the ACRS, ACRS. +. 9p21, ACRS. +. CIMT-P and ACRS. +. CIMT-P. +. 9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript). Conclusion: Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study.

AB - Objective: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. Methods: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n= 9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated. Results: The AUC of the ACRS, ACRS. +. 9p21, ACRS. +. CIMT-P and ACRS. +. CIMT-P. +. 9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript). Conclusion: Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study.

KW - 9p21

KW - Carotid intima media thickness

KW - Coronary heart disease

KW - Plaque

KW - Risk prediction

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The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study

Abstract

Bibliographical note

Keywords

UN SDGs

Access

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Cite this