The acquisition of purines by Trypanosomatids

Claudia C. Cohn, Michael Gottlieb

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31 Scopus citations


Parasites of the family Trypanosomatidae have an absolute requirement for purines, yet lack the intracellular machinery to synthesize their own purine ring de novo. As a result, the enzymes devoted to the transport and metabolism of purines are extremely important to the parasite. Here, Claudia Cohn and Michael Gottlieb emphasize the value of understanding purine salvage for the development of trypanocidal drugs, and discuss the putative transporters devoted to purine uptake.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalParasitology Today
Issue number6
StatePublished - Jun 1997

Bibliographical note

Funding Information:
CSC received support from the Achievement Rewards for College Scientists (ARCS) Foundation, Metropolitan Washington, DC CI ~anter.

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