TY - JOUR
T1 - The adenosine agonist N6-R-phenylisopropyladenosine (R-PIA) stimulates feeding in rats
AU - Levine, Allen S.
AU - Grace, Martha
AU - Krahn, Dean D.
AU - Billington, Charles J.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/1/16
Y1 - 1989/1/16
N2 - Administration of adenosine and agonists of the adenosine receptors to rats results in hypoactivity, hypothermia, muscle relaxation and antinociception. In the present study, we found that the adenosine ligand, N6-R-phenylisopropyladenosine (R-PIA), increased food intake in rats at a time in the day when rats normally eat very little food or none at all. Feeding was not reliably stimulated upon the first exposure to R-PIA, but was clearly increased following repeated administration of this agonist. Other adenosine agonists, namely 2-chloradenosine and 5′-N-ethylcarboxamide adenosine, failed to alter feeding after a single injection or after repeated exposure. The adenosine antagonist, caffeine, did not block R-PIA's effect on food intake, whereas the opioid antagonist, naloxone, blocked R-PIA-induced eating. These data suggest that R-PIA stimulates feeding independent of the A1 or A2 adenosine receptors.
AB - Administration of adenosine and agonists of the adenosine receptors to rats results in hypoactivity, hypothermia, muscle relaxation and antinociception. In the present study, we found that the adenosine ligand, N6-R-phenylisopropyladenosine (R-PIA), increased food intake in rats at a time in the day when rats normally eat very little food or none at all. Feeding was not reliably stimulated upon the first exposure to R-PIA, but was clearly increased following repeated administration of this agonist. Other adenosine agonists, namely 2-chloradenosine and 5′-N-ethylcarboxamide adenosine, failed to alter feeding after a single injection or after repeated exposure. The adenosine antagonist, caffeine, did not block R-PIA's effect on food intake, whereas the opioid antagonist, naloxone, blocked R-PIA-induced eating. These data suggest that R-PIA stimulates feeding independent of the A1 or A2 adenosine receptors.
KW - Adenosine
KW - Caffeine
KW - Feeding
KW - N-R-phenylisopropyladenosine receptor
KW - Naloxone
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U2 - 10.1016/0006-8993(89)91415-7
DO - 10.1016/0006-8993(89)91415-7
M3 - Article
C2 - 2702488
AN - SCOPUS:0024477990
SN - 0006-8993
VL - 477
SP - 280
EP - 285
JO - Brain Research
JF - Brain Research
IS - 1-2
ER -