The American Public Is Ready to Accept Human-Animal Chimera Research

Andrew T. Crane; Francis X. Shen; Jennifer L Brown; Warren Cormack; Mercedes Ruiz-Estevez; Joseph P. Voth; Tsutomu Sawai; Taichi Hatta; Misao Fujita; Walter C. Low

doi:10.1016/j.stemcr.2020.08.018

The American Public Is Ready to Accept Human-Animal Chimera Research

Andrew T. Crane, Francis X. Shen, Jennifer L Brown, Warren Cormack, Mercedes Ruiz-Estevez, Joseph P. Voth, Tsutomu Sawai, Taichi Hatta, Misao Fujita, Walter C. Low

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10 Scopus citations

Abstract

We report findings from a new survey of US public attitudes toward human-animal chimeric embryo (HACE) research, designed to compare with recently reported Japanese survey data. We find that 59% of the US public can personally accept the process of injecting human induced pluripotent stem cells into genetically modified swine embryos and having human tissues produced in a pig's body transplanted into a human. This is greater acceptance than in Japan, and there is even strong acceptance among those with strong religious affiliations and who self-identify as conservatives. We argue that strong public support for HACE research, as well as the emerging literature suggesting that humanization of research animals is very unlikely, should compel the NIH to lift its current moratorium on HACE research.

Original language	English (US)
Pages (from-to)	804-810
Number of pages	7
Journal	Stem Cell Reports
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.stemcr.2020.08.018
State	Published - Oct 13 2020

Bibliographical note

Funding Information:
For helpful research assistance, we thank Jennifer Novo and Sydney Diekmann. The study was funded with internal University of Minnesota Law School faculty grant funding (to F.X.S.) and the University of Minnesota Brain Sciences Fund (to W.C.L.).

Publisher Copyright:
© 2020 The Authors

Keywords

US public attitudes
blastocyst complementation
ethics and policy
gene editing
human-animal chimeric embryo

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title = "The American Public Is Ready to Accept Human-Animal Chimera Research",

abstract = "We report findings from a new survey of US public attitudes toward human-animal chimeric embryo (HACE) research, designed to compare with recently reported Japanese survey data. We find that 59% of the US public can personally accept the process of injecting human induced pluripotent stem cells into genetically modified swine embryos and having human tissues produced in a pig's body transplanted into a human. This is greater acceptance than in Japan, and there is even strong acceptance among those with strong religious affiliations and who self-identify as conservatives. We argue that strong public support for HACE research, as well as the emerging literature suggesting that humanization of research animals is very unlikely, should compel the NIH to lift its current moratorium on HACE research.",

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note = "Funding Information: For helpful research assistance, we thank Jennifer Novo and Sydney Diekmann. The study was funded with internal University of Minnesota Law School faculty grant funding (to F.X.S.) and the University of Minnesota Brain Sciences Fund (to W.C.L.). Publisher Copyright: {\textcopyright} 2020 The Authors",

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AU - Voth, Joseph P.

AU - Sawai, Tsutomu

AU - Hatta, Taichi

AU - Fujita, Misao

AU - Low, Walter C.

N1 - Funding Information: For helpful research assistance, we thank Jennifer Novo and Sydney Diekmann. The study was funded with internal University of Minnesota Law School faculty grant funding (to F.X.S.) and the University of Minnesota Brain Sciences Fund (to W.C.L.). Publisher Copyright: © 2020 The Authors

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The American Public Is Ready to Accept Human-Animal Chimera Research

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Keywords

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