TY - JOUR
T1 - The antifibrinolytic activity of sulfamylon solution
AU - Aldridge, Jeffrey H.
AU - Weisdorf, Daniel J
AU - Kucan, John O.
PY - 1988/8
Y1 - 1988/8
N2 - Sulfamylon (mafenide) solution, a potent experimental topical antimicrobial, is used in our burn unit to treat burn wounds both before and after skin grafting. The importance of fibrin to early graft adherence prompted this in vitro study of the effect of Sulfamylon upon fibrin clot. Assessing fibrinolysis by in vitro proteolysis of [125I] fibrin monomers, Sulfamylon, at relevant clinical concentrations, produced dose-related inhibition of streptokinase-mediated fibrinolysis. In addition, Sulfamylon had no intrinsic fibrinolytic activity. This antifibrinolytic property of Sulfamylon solution may, in vivo, protect against early graft loss when used on burn wounds and other potentially contaminated graft sites.
AB - Sulfamylon (mafenide) solution, a potent experimental topical antimicrobial, is used in our burn unit to treat burn wounds both before and after skin grafting. The importance of fibrin to early graft adherence prompted this in vitro study of the effect of Sulfamylon upon fibrin clot. Assessing fibrinolysis by in vitro proteolysis of [125I] fibrin monomers, Sulfamylon, at relevant clinical concentrations, produced dose-related inhibition of streptokinase-mediated fibrinolysis. In addition, Sulfamylon had no intrinsic fibrinolytic activity. This antifibrinolytic property of Sulfamylon solution may, in vivo, protect against early graft loss when used on burn wounds and other potentially contaminated graft sites.
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U2 - 10.1097/00006534-198808000-00012
DO - 10.1097/00006534-198808000-00012
M3 - Article
C2 - 3041428
AN - SCOPUS:0023678833
SN - 0032-1052
VL - 82
SP - 281
EP - 284
JO - Plastic and reconstructive surgery
JF - Plastic and reconstructive surgery
IS - 2
ER -