The APP A673T frequency differs between Nordic countries

Jonas Mengel-From; Bernard Jeune; Tienari Pentti; Matt McGue; Kaare Christensen; Lene Christiansen

doi:10.1016/j.neurobiolaging.2015.07.011

The APP A673T frequency differs between Nordic countries

Jonas Mengel-From, Bernard Jeune, Tienari Pentti, Matt McGue, Kaare Christensen, Lene Christiansen

Psychology (Twin Cities)

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A coding gene variant A673T (rs63750847) in the APP gene has recently been recognized as a protective variant of late-onset Alzheimer's Disease in a large Icelandic population and has been observed recurrently in populations from Nordic countries. The variant also was related to longevity in the Icelandic population. However, because of the extreme rarity of A673T in non-Nordic populations, the association with Alzheimer's disease has not yet been formally replicated. Because the variant has not been reported among the Danes, we aimed to study its frequency among healthy middle-age twins and oldest-old singletons and explore the possible effects on longevity and cognitive abilities. Surprisingly, only 1 of 3487 unrelated Danes carried the A673T variant, (0.014% [95% CI 0.000-0.080]), which was significantly lower than in the other Nordic countries averaging to 0.43% (95% CI 0.40-0.46). In conclusion, the A673T variant is rarer in Danes than other Nordic countries, thus precluding assessment of association with longevity or cognitive functioning.

Original language	English (US)
Pages (from-to)	2909.e1-2909.e4
Journal	Neurobiology of Aging
Volume	36
Issue number	10
DOIs	https://doi.org/10.1016/j.neurobiolaging.2015.07.011
State	Published - Oct 1 2015

Bibliographical note

Funding Information:
The authors thank Lilja Jansson and Steen Gregersen for technical assistance. The study was supported by a grant from the US National Institutes of Health / National Institute on Aging , Grant No. P01 AG08761 ; by a grant from The Danish Agency for Science, Technology and Innovation , Grant No. 09–070081 , the INTERREG 4 A programme Syddanmark-Schleswig-K.E.R.N, the European Union's Seventh Framework Programme (FP7/2007–2011) under grant agreement n° 259679 and by grants from the Brødrene Hartmanns , Hørslev Fonden , A.P. Møller og Hustru Chastine MC-kinney Møllers foundations , and the Helsinki University Central Hospital . The Danish Aging Research Center is supported by a grant from the VELUX Foundation .

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Aging
Alzheimers
Amyloid beta
Cognition
Dementia

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title = "The APP A673T frequency differs between Nordic countries",

abstract = "A coding gene variant A673T (rs63750847) in the APP gene has recently been recognized as a protective variant of late-onset Alzheimer's Disease in a large Icelandic population and has been observed recurrently in populations from Nordic countries. The variant also was related to longevity in the Icelandic population. However, because of the extreme rarity of A673T in non-Nordic populations, the association with Alzheimer's disease has not yet been formally replicated. Because the variant has not been reported among the Danes, we aimed to study its frequency among healthy middle-age twins and oldest-old singletons and explore the possible effects on longevity and cognitive abilities. Surprisingly, only 1 of 3487 unrelated Danes carried the A673T variant, (0.014% [95% CI 0.000-0.080]), which was significantly lower than in the other Nordic countries averaging to 0.43% (95% CI 0.40-0.46). In conclusion, the A673T variant is rarer in Danes than other Nordic countries, thus precluding assessment of association with longevity or cognitive functioning.",

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The APP A673T frequency differs between Nordic countries

Abstract

Bibliographical note

Keywords

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