The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis

Otto A. Sanchez, Daniel A. Duprez, Lori B. Daniels, Alan S. Maisel, James D. Otvos, Carmen A. Peralta, João A. Lima, Hossein Bahrami, David R. Jacobs

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background. The association between N-terminal pro B-type natriuretic peptide (NTproBNP) and blood levels of small and large LDL- and HDL- particle (P) concentration may not be linear throughout the whole range of NT-proBNP values. Methods. Linear spline regression analysis between NT-proBNP and lipoprotein particle concentrations was performed cross-sectionally in 5597 individuals from the Multi-Ethnic Study of Atherosclerosis adjusted for age, race, sex, body mass index, % of energy from saturated fats, intentional exercise, statin use, antihypertensive medication use, diabetes, IL-6 and estimated glomerular filtration rate. Spline knots were selected as the point at which the linear slope changed in these associations. Results. NT-proBNP was positively associated with large LDL-P and HDL-P, but inversely associated with small LDL-P and HDL-P, but only for NT-proBNP values below the knot (range: 100-200 pg/mL).

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
JournalMetabolism: clinical and experimental
Volume64
Issue number8
DOIs
StatePublished - 2015

Bibliographical note

Funding Information:
This research was supported by contract N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-TR-001079 from NCRR .

Keywords

  • Lipoprotein particles
  • MESA study
  • NT-proBNP
  • Nuclear magnetic
  • Resonance spectroscopy

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