The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis

Otto A. Sanchez; Daniel A. Duprez; Lori B. Daniels; Alan S. Maisel; James D. Otvos; Carmen A. Peralta; João A. Lima; Hossein Bahrami; David R. Jacobs

doi:10.1016/j.metabol.2015.04.001

The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis

Otto A. Sanchez, Daniel A. Duprez, Lori B. Daniels, Alan S. Maisel, James D. Otvos, Carmen A. Peralta, João A. Lima, Hossein Bahrami, David R. Jacobs

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background. The association between N-terminal pro B-type natriuretic peptide (NTproBNP) and blood levels of small and large LDL- and HDL- particle (P) concentration may not be linear throughout the whole range of NT-proBNP values. Methods. Linear spline regression analysis between NT-proBNP and lipoprotein particle concentrations was performed cross-sectionally in 5597 individuals from the Multi-Ethnic Study of Atherosclerosis adjusted for age, race, sex, body mass index, % of energy from saturated fats, intentional exercise, statin use, antihypertensive medication use, diabetes, IL-6 and estimated glomerular filtration rate. Spline knots were selected as the point at which the linear slope changed in these associations. Results. NT-proBNP was positively associated with large LDL-P and HDL-P, but inversely associated with small LDL-P and HDL-P, but only for NT-proBNP values below the knot (range: 100-200 pg/mL).

Original language	English (US)
Pages (from-to)	857-861
Number of pages	5
Journal	Metabolism: clinical and experimental
Volume	64
Issue number	8
DOIs	https://doi.org/10.1016/j.metabol.2015.04.001
State	Published - 2015

Bibliographical note

Funding Information:
This research was supported by contract N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-TR-001079 from NCRR .

Publisher Copyright:
© 2015 Published by Elsevier Inc.

Keywords

Lipoprotein particles
MESA study
NT-proBNP
Nuclear magnetic
Resonance spectroscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Sanchez, O. A., Duprez, D. A., Daniels, L. B., Maisel, A. S., Otvos, J. D., Peralta, C. A., Lima, J. A., Bahrami, H., & Jacobs, D. R. (2015). The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis. Metabolism: clinical and experimental, 64(8), 857-861. https://doi.org/10.1016/j.metabol.2015.04.001

The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis. / Sanchez, Otto A.; Duprez, Daniel A.; Daniels, Lori B. et al.
In: Metabolism: clinical and experimental, Vol. 64, No. 8, 2015, p. 857-861.

Research output: Contribution to journal › Article › peer-review

Sanchez, OA , Duprez, DA, Daniels, LB, Maisel, AS, Otvos, JD, Peralta, CA, Lima, JA, Bahrami, H & Jacobs, DR 2015, 'The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis', Metabolism: clinical and experimental, vol. 64, no. 8, pp. 857-861. https://doi.org/10.1016/j.metabol.2015.04.001

Sanchez OA , Duprez DA, Daniels LB, Maisel AS, Otvos JD, Peralta CA et al. The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis. Metabolism: clinical and experimental. 2015;64(8):857-861. doi: 10.1016/j.metabol.2015.04.001

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abstract = "Background. The association between N-terminal pro B-type natriuretic peptide (NTproBNP) and blood levels of small and large LDL- and HDL- particle (P) concentration may not be linear throughout the whole range of NT-proBNP values. Methods. Linear spline regression analysis between NT-proBNP and lipoprotein particle concentrations was performed cross-sectionally in 5597 individuals from the Multi-Ethnic Study of Atherosclerosis adjusted for age, race, sex, body mass index, % of energy from saturated fats, intentional exercise, statin use, antihypertensive medication use, diabetes, IL-6 and estimated glomerular filtration rate. Spline knots were selected as the point at which the linear slope changed in these associations. Results. NT-proBNP was positively associated with large LDL-P and HDL-P, but inversely associated with small LDL-P and HDL-P, but only for NT-proBNP values below the knot (range: 100-200 pg/mL).",

keywords = "Lipoprotein particles, MESA study, NT-proBNP, Nuclear magnetic, Resonance spectroscopy",

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note = "Funding Information: This research was supported by contract N01-HC-95169 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-TR-001079 from NCRR . Publisher Copyright: {\textcopyright} 2015 Published by Elsevier Inc.",

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AU - Duprez, Daniel A.

AU - Daniels, Lori B.

AU - Maisel, Alan S.

AU - Otvos, James D.

AU - Peralta, Carmen A.

AU - Lima, João A.

AU - Bahrami, Hossein

AU - Jacobs, David R.

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PY - 2015

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N2 - Background. The association between N-terminal pro B-type natriuretic peptide (NTproBNP) and blood levels of small and large LDL- and HDL- particle (P) concentration may not be linear throughout the whole range of NT-proBNP values. Methods. Linear spline regression analysis between NT-proBNP and lipoprotein particle concentrations was performed cross-sectionally in 5597 individuals from the Multi-Ethnic Study of Atherosclerosis adjusted for age, race, sex, body mass index, % of energy from saturated fats, intentional exercise, statin use, antihypertensive medication use, diabetes, IL-6 and estimated glomerular filtration rate. Spline knots were selected as the point at which the linear slope changed in these associations. Results. NT-proBNP was positively associated with large LDL-P and HDL-P, but inversely associated with small LDL-P and HDL-P, but only for NT-proBNP values below the knot (range: 100-200 pg/mL).

AB - Background. The association between N-terminal pro B-type natriuretic peptide (NTproBNP) and blood levels of small and large LDL- and HDL- particle (P) concentration may not be linear throughout the whole range of NT-proBNP values. Methods. Linear spline regression analysis between NT-proBNP and lipoprotein particle concentrations was performed cross-sectionally in 5597 individuals from the Multi-Ethnic Study of Atherosclerosis adjusted for age, race, sex, body mass index, % of energy from saturated fats, intentional exercise, statin use, antihypertensive medication use, diabetes, IL-6 and estimated glomerular filtration rate. Spline knots were selected as the point at which the linear slope changed in these associations. Results. NT-proBNP was positively associated with large LDL-P and HDL-P, but inversely associated with small LDL-P and HDL-P, but only for NT-proBNP values below the knot (range: 100-200 pg/mL).

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KW - MESA study

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KW - Nuclear magnetic

KW - Resonance spectroscopy

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The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis

Abstract

Bibliographical note

Keywords

UN SDGs

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