TY - JOUR
T1 - The association between non-steroidal anti-inflammatory drugs (NSAIDs) and myelodysplastic syndromes in the Adults in Minnesota with Myelodysplastic Syndromes (AIMMS) Study
AU - Hubbard, Aubrey K.
AU - Richardson, Michaela
AU - Rosesler, Michelle A.
AU - Cioc, Adina
AU - Nguyen, Phuong L.
AU - Warlick, Erica
AU - Poynter, Jenny N.
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Myelodysplastic syndromes (MDS) are a heterogeneous group of blood disorders. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a chemopreventive effect in some cancers. We evaluated associations between NSAID use and MDS in a population-based case-control study. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Secondary analyses stratified by sex and MDS subtype were also conducted.The analysis included 399 MDS cases and 698 controls. No significant associations between MDS and use of aspirin (OR = 0.87, 95% CI 0.67–1.14), ibuprofen (OR = 0.91, 95% CI 0.64–1.30), acetaminophen (OR = 1.29, 95% CI 0.90–1.84) or NSAIDs overall (OR = 0.92, 95% CI 0.68–1.23) were observed. No significant associations were observed in models stratified by sex or MDS subtype; however, the direction of the effect between NSAID use and MDS varied by MDS subtype. Our results do not support an association between NSAID use and MDS overall.
AB - Myelodysplastic syndromes (MDS) are a heterogeneous group of blood disorders. Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a chemopreventive effect in some cancers. We evaluated associations between NSAID use and MDS in a population-based case-control study. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Secondary analyses stratified by sex and MDS subtype were also conducted.The analysis included 399 MDS cases and 698 controls. No significant associations between MDS and use of aspirin (OR = 0.87, 95% CI 0.67–1.14), ibuprofen (OR = 0.91, 95% CI 0.64–1.30), acetaminophen (OR = 1.29, 95% CI 0.90–1.84) or NSAIDs overall (OR = 0.92, 95% CI 0.68–1.23) were observed. No significant associations were observed in models stratified by sex or MDS subtype; however, the direction of the effect between NSAID use and MDS varied by MDS subtype. Our results do not support an association between NSAID use and MDS overall.
KW - Myelodysplastic syndromes
KW - epidemiology
KW - non-steroidal anti-inflammatory drug
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U2 - 10.1080/10428194.2020.1869962
DO - 10.1080/10428194.2020.1869962
M3 - Article
C2 - 33416407
AN - SCOPUS:85099408411
SN - 1042-8194
VL - 62
SP - 1474
EP - 1481
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 6
ER -