The association of clinical conditions and serologic tests with CD4+ lymphocyte counts in HIV-infected subjects without AIDS

Alan R. Lifson, Nancy A. Hessol, Susan P. Buchbinder, Scott D. Holmberg

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Early intervention guidelines in HIV infection require knowledge of CD4+ lymphocyte count; however, CD4+ determinations require special laboratory procedures and may not be readily available in all situations. Using data from 207 HIV-seropositive homosexual men without AIDS, we evaluated the association of difference clinical conditions or serologic tests with CD4+ count. Men with conditions including seborrheic dermatitis, hairy leukoplakia, oral candidiasis and chronic diarrhea, and men with beta2-microglobulin levels ≥4.0mg/l had significantly lower CD4+ counts. However, the probability that a subject with such parameters had <200 x 106/l CD4+ cells was limited (25-63%) . Although the probability that a subject with such parameters had <500 x 106/l CD4+ cells was better (76-88%), the probability that a person without these parameters had ≥500 x 106/l CD4+ cells was only 45-50%. Clinical and serologic parameters may provide important prognostic information, but cannot be used to reliably determine the level of CD4+ cells.

Original languageEnglish (US)
Pages (from-to)1209-1215
Number of pages7
JournalAIDS
Volume5
Issue number10
StatePublished - Jan 1 1991

Keywords

  • Beta-microglobulin
  • CD4+ lymphocytes
  • HIV
  • Hairy leukoplakia
  • Homosexual and bisexual men
  • Oral candidiasis

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