Parkinson's disease continues to be described as a relatively homogenous nosological entity, characterised by the presence of four cardinal signs - bradykinesia, rigidity, tremor and postural instability - with a variable presence of other motor and non-motor symptoms (cognitive, behavioral, vegetative etc.); its pathological basis being the continuous progression of brain alpha-synucleinopathy. It seemed that this clinical entity might be relatively easily diagnosed using the United Kingdom Parkinson's Disease Brain Bank (UK-PDBB) clinical diagnostic criteria that are based on the results of a retrospective clinical and pathological study. However, substantial opinion shift occurred as a result of the recent intensive field research. A distinction has arbitrarily been made between Dementia with Lewy bodies and Parkinson's disease dementia. Several next mutations (PARK10-PARK13, PARK16-PARK18) encoding the manifestation of "sporadic", late-onset and typical Parkinson's disease have been added to the existing spectrum of familiar Parkinson's disease. Therefore, the term "Parkinson's disease" should be used for the "sporadic" form of the disease only. However, for the "definite" or "highly probable" level of diagnostic accuracy, the UK-PDBB criteria are less useful. The term "neurodegenerative Parkinsonism" would probably better reflect current level of diagnostic certainty referring to Parkinson's disease.
|Translated title of the contribution||The changing face of Parkinsonian neurodegeneration|
|Number of pages||9|
|Journal||Ceska a Slovenska Neurologie a Neurochirurgie|
|State||Published - Feb 13 2013|
- Hereditary parkinsonism
- Neurodegenerative parkinsonism
- Parkinson's disease