TY - JOUR
T1 - The dopamine system, Parkinson's disease and language function
AU - McNamara, Patrick
AU - Durso, Raymon
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2018/6
Y1 - 2018/6
N2 - The mesocortical dopaminergic system innervates two major forebrain networks important in language processing: the frontal–parietal network (FPN) and the ‘social brain’ network. We argue that the FPN may contribute to mediation of grammatical/syntactic aspects of language function while the social brain network may support pragmatic language processes. Patients with Parkinson's disease (PD) evidence deficits in both brain networks and both linguistic domains: on grammatical sentence processing tasks and on pragmatic language tasks. The pragmatic deficits appear to be more pervasive than the syntactic/grammatical deficits, though a theoretical account of these deficits is lacking. While dopaminergic systems likely contribute to modulation of speech acts in patients with PD, there is, as yet, no clear theoretical account of how that is accomplished.
AB - The mesocortical dopaminergic system innervates two major forebrain networks important in language processing: the frontal–parietal network (FPN) and the ‘social brain’ network. We argue that the FPN may contribute to mediation of grammatical/syntactic aspects of language function while the social brain network may support pragmatic language processes. Patients with Parkinson's disease (PD) evidence deficits in both brain networks and both linguistic domains: on grammatical sentence processing tasks and on pragmatic language tasks. The pragmatic deficits appear to be more pervasive than the syntactic/grammatical deficits, though a theoretical account of these deficits is lacking. While dopaminergic systems likely contribute to modulation of speech acts in patients with PD, there is, as yet, no clear theoretical account of how that is accomplished.
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U2 - 10.1016/j.cobeha.2017.10.010
DO - 10.1016/j.cobeha.2017.10.010
M3 - Review article
AN - SCOPUS:85033378315
SN - 2352-1546
VL - 21
SP - 1
EP - 5
JO - Current Opinion in Behavioral Sciences
JF - Current Opinion in Behavioral Sciences
ER -