In summary, blockade of the costimulatory CD28/B7 pathway inhibits, but does not eliminate GVHD. Blockade of the coinhibitory CTLA4/B7 pathway accelerates GVHD. The incomplete efficacy of blocking the CD28/B7 pathway suggested that other pathways may be contributing to the generation of a productive immune response culminating in GVHD lethality.
- Graft-versus-host disease
- Imaging T-cell tracking