The effect of aminoguanidine on the blood-retinal barrier in streptozocin-induced diabetic rats

H. K. Cho, H. Kozu, G. A. Peyman, G. J. Parry, B. Khoobehi

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22 Scopus citations

Abstract

The effect of aminoguanidine hydrochloride (AG) on the blood-retinal barrier was studied in rats with streptozocin-induced diabetes. Half of the rats were given AG (100 mg/kg/day) while the remainder received no treatment. Vitreous fluorophotometry was performed on all rats before STZ injection and 2 weeks after induction of diabetes mellitus. Two weeks after STZ injection the mean 60-minute vitreous fluorescein concentration following dye injection had increased more in the nontreated group than in the AG-treated group, suggesting that AG may have some beneficial effect on the breakdown of the blood-retinal barrier.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalOphthalmic surgery
Volume22
Issue number1
StatePublished - 1991

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