TY - JOUR
T1 - The effect of benzalkonium chloride on rabbit nasal mucosa in vivo
T2 - An electron microscopy study
AU - Cüreoǧlu, Sebahattin
AU - Akkuş, Murat
AU - Osma, Üstün
AU - Yaldiz, Mehmet
AU - Oktay, Faruk
AU - Can, Belgin
AU - Güven, Cengiz
AU - TekIn, Muhammet
AU - MerIç, Faruk
PY - 2002/9/17
Y1 - 2002/9/17
N2 - In this study we investigated the histopathological changes of nasal mucosa after the use of topical benzalkonium-chloride solution. In the study, 28 male New Zealand white rabbits were used. The animals were divided into two groups. In the first group, 50μl of 0.001% benzalkonium-chloride solution was sprayed into the right nostril and 50μl of 0.9% saline into the left twice daily for 14 days. In the second group, the same solutions were applied twice daily for 28 days. All of the biopsies from each nasal cavity were processed for electron microscopy. In the nostrils treated with 0.001% benzalkonium chloride, there were areas with obvious squamous cell metaplasia. Some cells showed broken cristae of the mitochondria. Degenerative changes in the supportive and olfactory cells, deformation of nuclei and the increase of heterochromatin were observed. The present investigation has shown that the application of topical benzalkonium chloride does induce degenerative morphologic changes in the nasal mucosa in rabbits in vivo.
AB - In this study we investigated the histopathological changes of nasal mucosa after the use of topical benzalkonium-chloride solution. In the study, 28 male New Zealand white rabbits were used. The animals were divided into two groups. In the first group, 50μl of 0.001% benzalkonium-chloride solution was sprayed into the right nostril and 50μl of 0.9% saline into the left twice daily for 14 days. In the second group, the same solutions were applied twice daily for 28 days. All of the biopsies from each nasal cavity were processed for electron microscopy. In the nostrils treated with 0.001% benzalkonium chloride, there were areas with obvious squamous cell metaplasia. Some cells showed broken cristae of the mitochondria. Degenerative changes in the supportive and olfactory cells, deformation of nuclei and the increase of heterochromatin were observed. The present investigation has shown that the application of topical benzalkonium chloride does induce degenerative morphologic changes in the nasal mucosa in rabbits in vivo.
KW - Benzalkonium chloride
KW - Nasal mucosa
KW - Preservative
KW - Steroids
KW - Topical nasal decongestants
UR - http://www.scopus.com/inward/record.url?scp=0036375377&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036375377&partnerID=8YFLogxK
M3 - Article
C2 - 12189401
AN - SCOPUS:0036375377
SN - 0937-4477
VL - 259
SP - 362
EP - 364
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
IS - 7
ER -