The effect of calcitonin gene-related peptide on food intake involves aversive mechanisms

D. D. Krahn; B. A. Gosnell; A. S. Levine; J. E. Morley

doi:10.1016/0091-3057(86)90035-3

The effect of calcitonin gene-related peptide on food intake involves aversive mechanisms

D. D. Krahn, B. A. Gosnell, A. S. Levine, J. E. Morley

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Calcitonin gene-related peptide (CGRP), the product of the calcitonin gene produced primarily in the central nervous system, has been shown to decrease food intake when administered intracerebroventricularly (ICV). Testing of CGRP (ICV) in both single bottle conditioned-aversion and differential starvation paradigms was done. In both paradigms, result using CGRP were consistent with those predicted for aversive agents. Therefore, CGRP apparently decreases feeding via aversive mechanisms.

Original language	English (US)
Pages (from-to)	5-7
Number of pages	3
Journal	Pharmacology, Biochemistry and Behavior
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(86)90035-3
State	Published - Jan 1986
Externally published	Yes

Keywords

Aversion
Calcitonin gene-related peptide
Feeding
Satiety

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PY - 1986/1

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AB - Calcitonin gene-related peptide (CGRP), the product of the calcitonin gene produced primarily in the central nervous system, has been shown to decrease food intake when administered intracerebroventricularly (ICV). Testing of CGRP (ICV) in both single bottle conditioned-aversion and differential starvation paradigms was done. In both paradigms, result using CGRP were consistent with those predicted for aversive agents. Therefore, CGRP apparently decreases feeding via aversive mechanisms.

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KW - Feeding

KW - Satiety

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The effect of calcitonin gene-related peptide on food intake involves aversive mechanisms

Abstract

Keywords

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