The effect of centrally administered naloxone on deprivation and drug-induced feeding

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Abstract

In the present study we evaluated the effect of intracerebroventricular (ICV) administration of naloxone on feeding induced by food deprivation, norepinephrine (NE), muscimol and neuropeptide Y (NPY). Naloxone (200, 100 and 50 μg ICV) decreased deprivation-induced feeding. In contrast, only the 200 μg dose of naloxone decreased NE-induced feeding and the 200 and 100 μg doses decreased muscimol-induced feeding. Eating stimulated by central administration of NPY was potently decreased by doses of naloxone ranging from 10-200 μg.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume36
Issue number2
DOIs
StatePublished - Jun 1990

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Food deprivation
  • Food intake
  • Muscimol
  • Naloxone
  • Neuropeptide Y
  • Norepinephrine

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