The effect of cholecystokinin octapeptide and glucagon (1-29) on food intake of weanling rats

S. A. Wager-Srdar; A. S. Levine

doi:10.1016/0031-9384(89)90289-8

The effect of cholecystokinin octapeptide and glucagon (1-29) on food intake of weanling rats

S. A. Wager-Srdar, A. S. Levine

Medicine - Administration

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Abstract

Cholecystokinin octapeptide (CCK-8) and glucagon (GLG) decrease food intake of a number of species. However, the responsiveness of rats to the food intake effects of these peptides may develop differentially due to sex, age and/or developmental state. Male and female weanling rats decreased early dark cycle food intake following the administration of 5 and 10 μg/kg CCK-8 and male rats were more responsive than female rats, p<0.05. GLG did not decrease early dark cycle food intake of either male or female weanling rats. Weanling male rats increased plasma glucose and insulin levels in response to GLG administration, p<0.05. Male rats were retested with GLG (250 and 500 μg/kg) at 6, 9 and 22 weeks of age. GLG did not decrease food intake of these rats until they reached 9 weeks of age and they were still responsive at 22 weeks of age, p<0.05.

Original language	English (US)
Pages (from-to)	747-751
Number of pages	5
Journal	Physiology and Behavior
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/0031-9384(89)90289-8
State	Published - Apr 1989

Keywords

Age
Food intake
Plasma insulin
Sex

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title = "The effect of cholecystokinin octapeptide and glucagon (1-29) on food intake of weanling rats",

abstract = "Cholecystokinin octapeptide (CCK-8) and glucagon (GLG) decrease food intake of a number of species. However, the responsiveness of rats to the food intake effects of these peptides may develop differentially due to sex, age and/or developmental state. Male and female weanling rats decreased early dark cycle food intake following the administration of 5 and 10 μg/kg CCK-8 and male rats were more responsive than female rats, p<0.05. GLG did not decrease early dark cycle food intake of either male or female weanling rats. Weanling male rats increased plasma glucose and insulin levels in response to GLG administration, p<0.05. Male rats were retested with GLG (250 and 500 μg/kg) at 6, 9 and 22 weeks of age. GLG did not decrease food intake of these rats until they reached 9 weeks of age and they were still responsive at 22 weeks of age, p<0.05.",

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T1 - The effect of cholecystokinin octapeptide and glucagon (1-29) on food intake of weanling rats

AU - Wager-Srdar, S. A.

AU - Levine, A. S.

PY - 1989/4

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N2 - Cholecystokinin octapeptide (CCK-8) and glucagon (GLG) decrease food intake of a number of species. However, the responsiveness of rats to the food intake effects of these peptides may develop differentially due to sex, age and/or developmental state. Male and female weanling rats decreased early dark cycle food intake following the administration of 5 and 10 μg/kg CCK-8 and male rats were more responsive than female rats, p<0.05. GLG did not decrease early dark cycle food intake of either male or female weanling rats. Weanling male rats increased plasma glucose and insulin levels in response to GLG administration, p<0.05. Male rats were retested with GLG (250 and 500 μg/kg) at 6, 9 and 22 weeks of age. GLG did not decrease food intake of these rats until they reached 9 weeks of age and they were still responsive at 22 weeks of age, p<0.05.

AB - Cholecystokinin octapeptide (CCK-8) and glucagon (GLG) decrease food intake of a number of species. However, the responsiveness of rats to the food intake effects of these peptides may develop differentially due to sex, age and/or developmental state. Male and female weanling rats decreased early dark cycle food intake following the administration of 5 and 10 μg/kg CCK-8 and male rats were more responsive than female rats, p<0.05. GLG did not decrease early dark cycle food intake of either male or female weanling rats. Weanling male rats increased plasma glucose and insulin levels in response to GLG administration, p<0.05. Male rats were retested with GLG (250 and 500 μg/kg) at 6, 9 and 22 weeks of age. GLG did not decrease food intake of these rats until they reached 9 weeks of age and they were still responsive at 22 weeks of age, p<0.05.

KW - Age

KW - Food intake

KW - Plasma insulin

KW - Sex

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The effect of cholecystokinin octapeptide and glucagon (1-29) on food intake of weanling rats

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