The effect of cold temperatures on biological systems

Jeunghwan Choi; Saravana B. Kumar; Silvia Jiang-Hughes; John C. Bischof

doi:10.1007/978-1-4471-6765-5_4

The effect of cold temperatures on biological systems

Jeunghwan Choi, Saravana B. Kumar, Silvia Jiang-Hughes, John C. Bischof

Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The mechanisms of cold injury to biosystems are investigated at the cellular, tissue, and systemic levels, with details concerning the related experimental methods. Cellular level studies have shown a direct relationship between biophysical changes versus freeze-thaw survival. Advances in experimental and analytical methods have resulted in qualitatively similar results for native and artificial tissue systems, with several important caveats relating to cell-cell, cell-ECM effects. While these biophysical events have informed a better understanding of immediate injury after freezing at the cell and tissue level, further understanding of delayed injury effects after cryosurgery including at the cellular (i.e. apoptosis) and host mediated (i.e. vascular and immunological) events remain important areas of research and an opportunity to improve the technique.

Original language	English (US)
Title of host publication	Dermatological Cryosurgery and Cryotherapy
Publisher	Springer London
Pages	19-36
Number of pages	18
ISBN (Electronic)	9781447167655
ISBN (Print)	9781447167648
DOIs	https://doi.org/10.1007/978-1-4471-6765-5_4
State	Published - Jan 1 2016

Keywords

Biophysics
Cryobiology
Cryomicroscopy
Cryosurgery
Differential scanning calorimetry
Freeze injury
Freeze substitution
Freeze-thaw
Freezing model

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abstract = "The mechanisms of cold injury to biosystems are investigated at the cellular, tissue, and systemic levels, with details concerning the related experimental methods. Cellular level studies have shown a direct relationship between biophysical changes versus freeze-thaw survival. Advances in experimental and analytical methods have resulted in qualitatively similar results for native and artificial tissue systems, with several important caveats relating to cell-cell, cell-ECM effects. While these biophysical events have informed a better understanding of immediate injury after freezing at the cell and tissue level, further understanding of delayed injury effects after cryosurgery including at the cellular (i.e. apoptosis) and host mediated (i.e. vascular and immunological) events remain important areas of research and an opportunity to improve the technique.",

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AU - Kumar, Saravana B.

AU - Jiang-Hughes, Silvia

AU - Bischof, John C.

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KW - Cryobiology

KW - Cryomicroscopy

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KW - Freeze-thaw

KW - Freezing model

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The effect of cold temperatures on biological systems

Abstract

Keywords

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