The effect of various dietary fiber sources on glycated hemoglobin and renal hypertrophy, two longterm indicators of blood glucose control, was studied in diabetic rats. Streptozotocin-treated rats were fed a fiber-free diet or diets containing 8% dietary fiber, using one of the following fiber sources: cellulose, sugar beet fiber, beet fiber treated with calcium carbonate, oat bran, rye bran, barley bran flour, wheat bran, or guar gum. After 28 days, only guar gumfeeding reduced the % glycated hemoglobin relative to the fiber-free control group. Renal hypertrophy was seen in animals from all diabetic groups and was not diminished by any of the fiber sources. In meal-fed animals there was no evidence of expansion of the intestinal contents volume by feeding of any fiber source. Guar gum substantially increased the viscosity of the intestinal contents in 3 of 4 animals. The results are consistent with the use of purified, highly viscous fiber sources for improving glycemic control in insulin-dependent diabetes.
Bibliographical noteFunding Information:
ipresented in part at the 72nd Annual Meeting of the Federationo f AmericanS ocietieso f Experimental Biology, Las Vegas, NV, May I-5, 1988 [Gallaher,D . D., Schaubert,D . R., & Surley, C. (1988) Dietary fiber in 10ng-termb lood glucose control and kidney hypertrophyi n the diabeticr at. FASEBJ. 2:A856 (abs.)] +Supported in part by a grant fr0m the AmericanC rystal Sugar Co., M00rhead, NN. 3present address: Departmento f Food Sciencea nd Nutrition, 1334 Eckles Avenue, Universityo f Minnesota, St. Paul, HN 55108.
- dietary fiber
- glycated hemoglobin
- renal hypertrophy