TY - GEN
T1 - The effect of feedback on alternans formation in the heart
AU - McIntyre, Stephen D.
AU - Mori, Yoichiro
AU - Tolkacheva, Elena G.
PY - 2012
Y1 - 2012
N2 - A beat-to-beat alternation in the duration of the action potential (APD) of myocytes, i.e. alternans, is believed to be a direct precursor of ventricular fibrillation (VF) in the whole heart. A common technique for the prediction of alternans uses the restitution curve, the nonlinear functional relationship between the APD and the preceding diastolic interval (DI). It was proposed that alternans appears when the magnitude of the slope of the restitution curve exceeds one, known as the restitution hypothesis. However, this restitution hypothesis was derived in the presence of feedback, i.e. the partial dependence of the DI on the immediate preceding APD. Physiologically, the heart rate exhibits substantial variations, known as heart rate variability (HRV), which might affect the feedback relationship. In this manuscript, we aim to investigate the effect of feedback on alternans formation in the heart.
AB - A beat-to-beat alternation in the duration of the action potential (APD) of myocytes, i.e. alternans, is believed to be a direct precursor of ventricular fibrillation (VF) in the whole heart. A common technique for the prediction of alternans uses the restitution curve, the nonlinear functional relationship between the APD and the preceding diastolic interval (DI). It was proposed that alternans appears when the magnitude of the slope of the restitution curve exceeds one, known as the restitution hypothesis. However, this restitution hypothesis was derived in the presence of feedback, i.e. the partial dependence of the DI on the immediate preceding APD. Physiologically, the heart rate exhibits substantial variations, known as heart rate variability (HRV), which might affect the feedback relationship. In this manuscript, we aim to investigate the effect of feedback on alternans formation in the heart.
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U2 - 10.1115/DSCC2012-MOVIC2012-8646
DO - 10.1115/DSCC2012-MOVIC2012-8646
M3 - Conference contribution
AN - SCOPUS:84885929064
SN - 9780791845295
T3 - ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
SP - 585
EP - 589
BT - ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
T2 - ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
Y2 - 17 October 2012 through 19 October 2012
ER -