Fifteen patients with chronic renal failure had depressed neutrophil chemotactic responsiveness following several hemodialysis treatments. The chemotactic index (C.I.) of these patients was 12.7 ± 6.4 as compared with 72.8 ± 22.7 for controls (p < 0.001). Patients with chronic renal failure, not on hemodialysis, had only mildly depressed neutrophil chemotactic responsiveness (42.3 ± 15; p < 0.01). Thus, hemodialysis impairs neutrophil function and may contribute to the increased risk of infection in uremic patients. Chemotactic responsiveness returned to normal in three patients following renal transplantation.
|Original language||English (US)|
|Number of pages||4|
|Journal||The Journal of laboratory and clinical medicine|
|State||Published - Dec 1976|