The effect of hydroxyapatite/gemosil nanocomposites on extracellular matrix patterning through the promotion of osteoblast self-organization

Ching Chang Ko, Alice Ma, Masaru Kaku, Kai Li Liu, T. J.M. Luo, J. F.C. Tulloch, Wei-Shou Hu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It was hypothesized that the hydroxyapatite(HAP)/GEMOSIL biomaterial could promote osteoblast (MC3T3) self-organization. This study using MC3T3 cell line demonstrated formation of trabecular bone-like extracellular matrix (ECM) on the material compared to unorganized ECM on the control (no-material). The study also initiated exploratory tests for the underlying mechanisms via gene analysis and proliferation assay.

Original languageEnglish (US)
Title of host publication8th World Biomaterials Congress 2008
Number of pages1
StatePublished - Dec 1 2008
Event8th World Biomaterials Congress 2008, WBC 2008 - Amsterdam, Netherlands
Duration: May 28 2008Jun 1 2008

Publication series

Name8th World Biomaterials Congress 2008
Volume2

Other

Other8th World Biomaterials Congress 2008, WBC 2008
CountryNetherlands
CityAmsterdam
Period5/28/086/1/08

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