The effect of individual antiretroviral drugs on body composition in HIV-infected persons initiating highly active antiretroviral therapy

Judith C. Shlay, Shweta Sharma, Grace Peng, Cynthia L. Gibert, Carl Grunfeld

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

OBJECTIVE: To examine the long-term effects of individual antiretroviral drugs on body composition among 416 persons initiating antiretroviral therapy (ART). METHODS: In a substudy of a clinical trial of persons initiating ART, changes in body composition attributable to individual ART were examined. ARTs assessed were as follows: indinavir, ritonavir, nelfinavir, efavirenz, nevirapine, stavudine (d4T), zidovudine (ZDV), lamivudine (3TC), didanosine, and abacavir. Skinfolds and circumferences were measured at baseline and every 4 months. Mid arm, mid thigh, and waist subcutaneous tissue areas and nonsubcutaneous tissue areas were calculated. Rates of change per year of exposure to each individual ART drug were determined using multivariate longitudinal regression. RESULTS: d4T and ZDV use was associated with losses in subcutaneous tissue area and skinfold thickness. 3TC use was associated with gains in all subcutaneous tissue areas and skinfold thickness, whereas abacavir use was associated with an increase in waist subcutaneous tissue area. Indinavir was associated with gains in waist subcutaneous tissue area, whereas indinavir, efavirenz, and nevirapine were associated with increases in upper back skinfolds. d4T use was also associated with increases in all nonsubcutaneous tissue areas; 3TC use was associated with the greatest increase in waist nonsubcutaneous tissue area. CONCLUSION: In this prospective nonrandomized evaluation, the nucleoside reverse transcriptase inhibitors d4T and ZDV were associated with decreases in subcutaneous tissue areas, whereas 3TC use was associated with increased subcutaneous tissue areas and waist nonsubcutaneous tissue area.

Original languageEnglish (US)
Pages (from-to)298-304
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume51
Issue number3
DOIs
StatePublished - Jul 2009

Keywords

  • Adverse effects
  • Antiretroviral drugs
  • Body composition
  • HIV
  • Lipodystrophy

Fingerprint

Dive into the research topics of 'The effect of individual antiretroviral drugs on body composition in HIV-infected persons initiating highly active antiretroviral therapy'. Together they form a unique fingerprint.

Cite this