The effect of naloxone on feeding and spontaneous locomotion in the wolf

John E. Morley, Allen S. Levine, Edward D. Plotka, Ulysses S. Seal

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The effect of naloxone on food intake and activity levels was studied in the wolf (Canis lupus). Naloxone decreased food intake at both the 1 mg/kg and 5 mg/kg dose. There was no quantitative difference in the magnitude of the decrease in food intake produced by naloxone in winter or summer. Wolves ate significantly greater amounts of deer meat than dog chow after naloxone when expressed on a mass basis but there was no difference when the amounts of food ingested were expressed in calories. This suggests a role for endogenous opiates in the regulation of energy intake. The putative satiety factor, cholecystokinin-octapeptide, had no effect on food intake in wolves. Naloxone decreased spontaneous locomotion and increased time spent resting in wolves. The effects of naloxone on activity were significantly more marked in winter compared to summer.

Original languageEnglish (US)
Pages (from-to)331-334
Number of pages4
JournalPhysiology and Behavior
Volume30
Issue number3
DOIs
StatePublished - Mar 1983

Keywords

  • Activity
  • Appetite
  • CCK
  • Endorphins
  • Energy regulation
  • Enkephalins
  • Feeding behavior
  • Naloxone
  • Wolf

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