The effect of peripheral administration of peptides on food intake, glucose and insulin in wolf pups

J. E. Morley, A. S. Levine, H. Hertel, T. Tandeski, U. S. Seal

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In the studies reported here we demonstrate that bombesin decreases food intake in wolf (Canis lupus) pups without altering glucose or insulin levels. A high dose of cholecystokinin-octapeptide (CCK, 5 μg/kg) decreased food intake. CCK produced a transient increase in insulin, without altering glucose. Glucagon (0.5 mg/kg) failed to decrease food intake despite producing a marked hyperglycemia and hyperinsulinemia. Calcitonin was ineffective at decreasing food intake, although it did decrease the time spent feeding. These studies suggest a potential role for peripheral peptides in food regulation in the wolf.

Original languageEnglish (US)
Pages (from-to)969-972
Number of pages4
JournalPeptides
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1986

Keywords

  • Bombesin
  • Calcitonin
  • Cholecystokinin
  • Food Intake
  • Glucagon
  • Glucose
  • Insulin

Fingerprint Dive into the research topics of 'The effect of peripheral administration of peptides on food intake, glucose and insulin in wolf pups'. Together they form a unique fingerprint.

Cite this