The effect of prostaglandins (PGE2 and PGF2α) on food intake in rats

Allen S. Levine; John E. Morley

doi:10.1016/0091-3057(81)90014-9

The effect of prostaglandins (PGE₂ and PGF_2α) on food intake in rats

Allen S. Levine, John E. Morley

Medicine - Administration

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Intracerebroventricular administration of PGF_2α and PGE₂ suppressed food intake in several feeding models. PGF_2α (20 μg) and PGE₂ (20 μg to 1 μg) suppressed food intake following a 24 hour starvation. PGF_2α (20 μg) and PGE₂ (20 μg) suppressed food intake following central administration of the feeding induces norepinephrine and muscimol. These prostaglandins also suppressed stress induced eating using the tail pinch model at doses of 20 μg, 10 μg and 5 μg with eating returning to control levels at the 1 μg dose. D-Ala Methionine Enkephalin failed to alter the suppressive effects of PGF_2α and PGE₂ at a dose of 1 μg but successfully reversed the effect of PGF_2α at a 10 μg dose while still having no effect on PGE₂ suppression of feeding.

Original language	English (US)
Pages (from-to)	735-738
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(81)90014-9
State	Published - Nov 1981

Keywords

Food intake
Prostaglandins
Stress induced eating
Tail pinch

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abstract = "Intracerebroventricular administration of PGF2α and PGE2 suppressed food intake in several feeding models. PGF2α (20 μg) and PGE2 (20 μg to 1 μg) suppressed food intake following a 24 hour starvation. PGF2α (20 μg) and PGE2 (20 μg) suppressed food intake following central administration of the feeding induces norepinephrine and muscimol. These prostaglandins also suppressed stress induced eating using the tail pinch model at doses of 20 μg, 10 μg and 5 μg with eating returning to control levels at the 1 μg dose. D-Ala Methionine Enkephalin failed to alter the suppressive effects of PGF2α and PGE2 at a dose of 1 μg but successfully reversed the effect of PGF2α at a 10 μg dose while still having no effect on PGE2 suppression of feeding.",

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