The effects of cell density and metabolite flux on cellular dynamics

Hans G. Othmer, John A. Aldridge

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Density-dependent regulation of cell growth in tissue culture is a well-known phenomenon but the mechanism of regulation remains obscure. Here we explore the effects of cell density and metabolite flux on the collective dynamics of a cell population. The intracellular dynamics are modelled by positive feedback kinetic mechanisms of the kind known to apply to yeast cells. Several experimental observations related to glycolytic oscillations are predicted and it is suggested that the general conclusions may be applicable in a broader context.

Original languageEnglish (US)
Pages (from-to)169-200
Number of pages32
JournalJournal of Mathematical Biology
Volume5
Issue number2
DOIs
StatePublished - Jun 1978

Keywords

  • Density-dependent growth control
  • Glycolytic oscillations

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