Abstract
The present study examined the degree to which the P300 component of the visual brain event-related potential and associated task performance deficits often observed in children with attention-deficit hyperactivity disorder (ADHD) are attributable to comorbid childhood disruptive disorders using a community sample of 11-year olds from the Minnesota Twin Family Study. Subjects were divided into "ADHD-pure" (ADHD without oppositional defiant disorder, ODD, or conduct disorder, CD), "ADHD-comorbid" (ADHD with ODD or CD), and comparison (no childhood disruptive disorder) groups using DSM-III-R diagnoses. Results showed that ADHD-comorbid but not ADHD-pure subjects displayed significant P3 amplitude reduction and poorer task performance compared to controls. No group effects for P3 latency or reaction time were seen. Although ADHD-comorbid children had marginally more ADHD symptoms compared to ADHD-pure children, this did not account for their reduced P3, suggesting that the observed neurobehavioral deficits reflected the effects of co-occurring childhood disruptive disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 329-336 |
| Number of pages | 8 |
| Journal | Biological Psychology |
| Volume | 79 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 2008 |
Bibliographical note
Funding Information:This research was supported by NIH grants DA 13240, DA 05147, DA 024417, and AA09367.
Keywords
- ADHD
- Childhood disruptive disorders
- Comorbidity
- Disinhibition
- Event-related potentials
- P3