The effects of conjugated deferoxamine in porcine skin flaps

David B. Hom, George S. Goding, Julie A. Price, Kerri J. Pernell, Robert H. Maisel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background. The free radical scavenger, deferoxamine (DFO) has been shown to reduce skin flap necrosis; however, its shortcomings are its toxicity and short plasma half-life. Methods. This study investigates the effects of the less toxic, )longer acting conjugated form, DFO-Hespan (DFO-H), to ischemic porcine skin flaps. During the study, DFO-H plasma concentrations and flap viability were evaluated over 10 days. Results. Steady DFO serum levels were maintained with no evidence of systemic side effects. However, DFO-H was not effective in increasing porcine skin flap viability. Mean treated flap viability (n = 18) was 36.2% ± 1.7% (mean ± SE) vs control (n = 16) 35.8% ± 2.6%, p = .9. Conclusion. DFO-H conjugation increases its half-life and its systemic tolerance for DFO. However, this conjugation may also reduce DFO's effectiveness to preserve flap survival probably by decreasing its ability to reach the intracellular oxygen free radicals. In addition, further studies are needed to investigate whether longer DFO administration given postoperatively can be more effective in reducing ischemic injury. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalHead and Neck
Volume22
Issue number6
DOIs
StatePublished - Sep 12 2000

Keywords

  • Free radical scavengers
  • Surgical flaps
  • Tissue survival

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