The effects of intravaginal clindamycin and metronidazole therapy on vaginal Mobiluncus morphotypes in patients with bacterial vaginosis

Paul Nyirjesy, Matthew J. McIntosh, Jana I. Steinmetz, Robert J. Schumacher, James L. Joffrion

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

OBJECTIVE: The objective of this study was to compare the effects of treatments for bacterial vaginosis (BV) on vaginal Mobiluncus morphotypes. STUDY DESIGN: Analyses were performed on Mobiluncus scores from similarly conducted studies evaluating clindamycin vaginal single-dose cream (CVSDC) or metronidazole vaginal gel (MVG) in 55 patients with BV and with Mobiluncus morphotypes at baseline. RESULTS: Both treatment groups demonstrated significant reductions in Mobiluncus score. However, the Mobiluncus score at test-of-cure was lower in the CVSDC than in the MVG group (P = 0.0471). More patients in the CVSDC group than in the MVG group achieved microbiologic (57.5% vs. 26.7%; P = 0.04), clinical (57.5% vs. 26.7%; P = 0.04), and therapeutic cures of BV (45.0% vs. 20.0%; P = 0.09). CONCLUSION: Clindamycin reduces vaginal Mobiluncus morphotypes to a greater extent than metronidazole in patients with BV; this correlates with a higher BV cure rate.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalSexually Transmitted Diseases
Volume34
Issue number4
DOIs
StatePublished - Apr 2007

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