TY - JOUR
T1 - The effects of intravaginal clindamycin and metronidazole therapy on vaginal Mobiluncus morphotypes in patients with bacterial vaginosis
AU - Nyirjesy, Paul
AU - McIntosh, Matthew J.
AU - Steinmetz, Jana I.
AU - Schumacher, Robert J.
AU - Joffrion, James L.
PY - 2007/4
Y1 - 2007/4
N2 - OBJECTIVE: The objective of this study was to compare the effects of treatments for bacterial vaginosis (BV) on vaginal Mobiluncus morphotypes. STUDY DESIGN: Analyses were performed on Mobiluncus scores from similarly conducted studies evaluating clindamycin vaginal single-dose cream (CVSDC) or metronidazole vaginal gel (MVG) in 55 patients with BV and with Mobiluncus morphotypes at baseline. RESULTS: Both treatment groups demonstrated significant reductions in Mobiluncus score. However, the Mobiluncus score at test-of-cure was lower in the CVSDC than in the MVG group (P = 0.0471). More patients in the CVSDC group than in the MVG group achieved microbiologic (57.5% vs. 26.7%; P = 0.04), clinical (57.5% vs. 26.7%; P = 0.04), and therapeutic cures of BV (45.0% vs. 20.0%; P = 0.09). CONCLUSION: Clindamycin reduces vaginal Mobiluncus morphotypes to a greater extent than metronidazole in patients with BV; this correlates with a higher BV cure rate.
AB - OBJECTIVE: The objective of this study was to compare the effects of treatments for bacterial vaginosis (BV) on vaginal Mobiluncus morphotypes. STUDY DESIGN: Analyses were performed on Mobiluncus scores from similarly conducted studies evaluating clindamycin vaginal single-dose cream (CVSDC) or metronidazole vaginal gel (MVG) in 55 patients with BV and with Mobiluncus morphotypes at baseline. RESULTS: Both treatment groups demonstrated significant reductions in Mobiluncus score. However, the Mobiluncus score at test-of-cure was lower in the CVSDC than in the MVG group (P = 0.0471). More patients in the CVSDC group than in the MVG group achieved microbiologic (57.5% vs. 26.7%; P = 0.04), clinical (57.5% vs. 26.7%; P = 0.04), and therapeutic cures of BV (45.0% vs. 20.0%; P = 0.09). CONCLUSION: Clindamycin reduces vaginal Mobiluncus morphotypes to a greater extent than metronidazole in patients with BV; this correlates with a higher BV cure rate.
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U2 - 10.1097/01.olq.0000235152.98601.d7
DO - 10.1097/01.olq.0000235152.98601.d7
M3 - Article
C2 - 17179772
AN - SCOPUS:34247266787
SN - 0148-5717
VL - 34
SP - 197
EP - 202
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
IS - 4
ER -